Int J Infect Dis . Morbidity and mortality with RSV infection in hospitalized adults. Comparison with seasonal influenza

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Int J Infect Dis


. 2020 Nov 26;S1201-9712(20)32498-X.
doi: 10.1016/j.ijid.2020.11.185. Online ahead of print.
Morbidity and mortality with RSV infection in hospitalized adults. Comparison with seasonal influenza


Alaa Atamna ¹ , Tanya Babich ² , Dafi Froimovici ³ , Dafna Yahav ⁴ , Nadav Sorek ⁵ , Haim Ben-Zvi ⁵ , Leonard Leibovici ² , Jihad Bishara ⁴ , Tomer Avni ⁶



Affiliations

• PMID: 33249288
• DOI: 10.1016/j.ijid.2020.11.185

Free article

Abstract

Introduction: RSV is considered a major pathogen that causes acute influenza like illness.
Objectives: To compare the clinical outcomes of patients with laboratory-confirmed RSV or influenza infection.
Methods: Adults hospitalized in Beilinson Hospital (October 2017-April 2018) with laboratory-confirmed RSV and influenza.
Primary outcome: composite of RSV/influenza complications: 30-day mortality, pneumonia, mechanical-ventilation, vasopressor-support, ICU admission, myocarditis/encephalitis.
Secondary outcomes: individual components of primary outcome, 90-day mortality, 90-days readmission and length of hospital stay.
Results: 639 patients were included: RSV(113) and influenza(526). The composite outcome was 21.4%(136/633), and was higher in RSV patients [30% (34/113)vs.19% (102/526),p = 0.002]. Pneumonia was more common in RSV patients [21.2% (24/113)vs.9.1% (48/526),p = 0.001]. On multivariable analysis, hypoalbuminemia (OR = 3.3, 95%CI 2.1-5.3, p < 0.001), reduced room-air saturation (OR = 1.1, 95%CI 1.02-1.1; p = 0.001) and infection with RSV (OR = 1.67, 95%CI 1.01-2.76, p = 0.046) were predictors for complications.
Conclusion: RSV infection in hospitalized adults resulted in serious respiratory illness with complications that are comparable with those caused by influenza.

Keywords: RSV; influenza; mortality; outcomes; respiratory syncytial virus.