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J Infect Dis
. 2020 Jun 19;jiaa331.
doi: 10.1093/infdis/jiaa331. Online ahead of print.
Epidemiology of Respiratory Syncytial Virus Across Five Influenza Seasons Among Adults and Children One Year of Age and Older - Washington State, 2011/12 - 2015/16
Michael L Jackson 1 , Emily Scott 2 , Jane Kuypers 2 , Arun K Nalla 2 , Pavitra Roychoudury 2 , Helen Y Chu 2
Affiliations
- PMID: 32556287
- DOI: 10.1093/infdis/jiaa331
Abstract
Background: Vaccines and novel prophylactics against respiratory syncytial virus (RSV) are in development. To provide a baseline for evaluating these interventions, we characterized the incidence and molecular epidemiology of RSV in persons aged ≥1 year.
Methods: We identified patients with medically-attended acute respiratory illness (MAARI) from the 2011/12 through 2015/16 influenza seasons among members of Kaiser Permanente Washington. We estimated the cumulative incidence of MAARI for laboratory-confirmed RSV or influenza infection.
Results: Annual cohorts ranged from 82,266 to 162,633 individuals, of whom 14% were children aged 1 to 17 years. Cumulative incidence of RSV each season ranged from 14 per 1,000 population (95% confidence interval [CI], 12-16) to 22 per 1,000 (95% CI, 19-25). Incidence of RSV was greater than influenza in children aged 12-23 months and 2-4 years; incidence of influenza was greater in other age groups. RSV subtype A dominated in 2011/12, 2012/13, and 2015/16, with ON1 being the most common genotype. RSV subtype B dominated in 2013/14 and 2014/15, primarily of the BA genotype.
Conclusions: The burden of RSV is comparable to that of influenza across the life course. These results provide a baseline for evaluating the impact of new RSV interventions on the epidemiology of RSV.
Keywords: adults; children; epidemiology; phylogenetic analysis; respiratory syncytial virus.