J Infect Dis . Estimation of Seasonal Influenza Attack Rates and Antibody Dynamics in Children Using Cross-Sectional Serological Data

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J Infect Dis


. 2020 Jun 18;jiaa338.
doi: 10.1093/infdis/jiaa338. Online ahead of print.
Estimation of Seasonal Influenza Attack Rates and Antibody Dynamics in Children Using Cross-Sectional Serological Data


Amanda Minter ¹ , Katja Hoschler ² , Ya Jankey Jagne ³ , Hadijatou Sallah ³ , Edwin Armitage ³ , Benjamin Lindsey ³ , James A Hay ^{4 5} , Steven Riley ⁴ , Thushan I de Silva ^{3 6} , Adam Kucharski ¹



Affiliations

• PMID: 32556290
• DOI: 10.1093/infdis/jiaa338

Abstract

Directly measuring evidence of influenza infections is difficult, especially in low surveillance settings such as sub-Saharan Africa. Using a Bayesian model, we estimated unobserved infection times and underlying antibody responses to influenza A/H3N2 using cross-sectional serum antibody responses to four strains in children aged 24-60 months. Among the 242 individuals, we estimated a variable seasonal attack rate and found that most children had at least one infection before two years of age. Our results are consistent with previously published high attack rates in children. The modelling approach highlights how cross-sectional serological data can be used to estimate epidemiological dynamics.

Keywords: : Influenza; Bayesian model; The Gambia; childhood infection; serology.