Clinical and epidemiological characterization of healthcare acquired influenza in critical ill patients

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Rev Chilena Infectol. 2019 Jun;36(3):274-282. doi: 10.4067/S0716-10182019000300274. [Clinical and epidemiological characterization of healthcare acquired influenza in critical ill patients].

[Article in Spanish]

Guti?rrez V¹, Cerda J², Le Corre N³, Medina R⁴, Ferr?s M³.
Author information

1 Enfermedades Infecciosas del Ni?o, Departamento de Enfermedades Infecciosas e Inmunolog?a Pedi?trica, Pontificia Universidad Cat?lica de Chile, Santiago, Chile. 2 Departamento de Salud P?blica, Pontificia Universidad Cat?lica de Chile, Santiago, Chile. 3 Departamento de Enfermedades Infecciosas e Inmunolog?a Pedi?trica, Laboratorio de Infectolog?a y Virolog?a Molecular, Pontificia Universidad Cat?lica de Chile, Santiago, Chile. 4 Laboratorio de Virolog?a Molecula, Departamento de Enfermedades Infecciosas e Inmunolog?a Pedi?tricar, Pontificia Universidad Cat?lica de Chile, Santiago, Chile.

Abstract

BACKGROUND:

Healthcare-associated infections (HAIs) increase morbidity and mortality. During 2014, at the Hospital Clinico Red de Salud UC Christus (RS-UCCH) it was estimated that 15% of respiratory viral infections were acquired during hospitalization and influenza A was more frequent.
AIMS:

Clinical and epidemiological characterization of HAIs due to influenza virus in patients hospitalized in critical care units (CCU) and special care.
METHODS:

Descriptive study. We included patients hospitalized in CCU and special care with hospital acquired influenza during 2014-2017. HAI due to influenza was defined as: symptom onset and/or positive influenza PCR after ≥ 48 hours of hospital admission, without previous respiratory symptoms or previous negative influenza test study.
RESULTS:

22 patients were identified, median age was 74 years. Influenza was acquired average on day 13. Influenza A was detected in 77% and 27% had respiratory co-infection. Thirteen (59%) were hospitalized in CCU, only 2 (15%) due to lung problems. Comorbidity was present in 86% and decompensation in 50%. Only 41% received influenza vaccine. The associated lethality was 18%.
CONCLUSIONS:

HAI due to influenza occurred in chronic, older and unvaccinated patients. Education about HAIs and continuous high vaccination coverage must be reinforced.


PMID: 31859745 DOI: 10.4067/S0716-10182019000300274
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