Host characteristics predict outcome among adult patients admitted by severe acute respiratory infection

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Rev Med Chil. 2019 Jul;147(7):842-851. doi: 10.4067/S0034-98872019000700842. Host characteristics predict outcome among adult patients admitted by severe acute respiratory infection.

Fica A¹, Pinto F¹, Sotomayor V², Fasce R³, Andrade W³, Dabanch J¹, Soto A¹, Triantafilo V⁴.
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1 Servicio de Infectolog?a, Hospital Militar de Santiago, Santiago, Chile. 2 Departamento de Epidemiolog?a, Ministerio de Salud, Santiago, Chile. 3 Subdepartamento de Enfermedades Virales, Instituto de Salud P?blica de Chile, Santiago, Chile. 4 Laboratorio Central, Hospital Militar de Santiago, Santiago, Chile.

Abstract

BACKGROUND:

Except for influenza pandemics, different observational studies have failed to demonstrate differences in mortality between various etiologies in adult patients hospitalized for respiratory infections.
AIM:

To compare clinical and mortality differences between different viral pathogens associated with severe acute respiratory infections (SARI) in hospitalized adults.
MATERIAL AND METHODS:

One-year prospective study in a sentinel center. We included 132 patients with SARI hospitalized for any of the nine viruses under study by PCR. Clinical variables were compared, excluding cases of coinfection.
RESULTS:

A viral coinfection was identified in 12% and influenza infection in 56% of cases. Eighty percent of patients were aged ≥ 65 years, with a high frequency of comorbidities, 27% were bedridden. Twenty four percent were admitted to critical care units, 20% required ventilatory assistance and 16% died. Cases occurred throughout the year, with an expected seasonal peak between autumn and spring and a predominance of infections not associated with influenza during summer months. In the multivariate analysis, only being bedridden was significantly associated with mortality at discharge (Odds ratio 23.46; 95% confidence intervals 3.33-165.12, p < 0.01), without association with age, comorbidity, viral pathogen involved, laboratory parameters, clinical presentation or CURB65 score. No major clinical dissimilarities were found between different viral pathogens.
CONCLUSIONS:

In our series of patients, mostly elderly, only bedridden status was significantly associated with mortality at discharge in patients hospitalized for SARI. Viral pathogens were not relevant.


PMID: 31859982 DOI: 10.4067/S0034-98872019000700842
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