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Complete genome sequence of a novel reassortant H3N3 avian influenza virus

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  • Complete genome sequence of a novel reassortant H3N3 avian influenza virus

    Arch Virol. 2019 Aug 27. doi: 10.1007/s00705-019-04386-8. [Epub ahead of print]
    Complete genome sequence of a novel reassortant H3N3 avian influenza virus.

    Le TB1,2, Kim HK3, Le HY1,2, Jeong MC1,2, Kim IK4, Jeong DG5,6, Yoon SW7,8.
    Author information

    1 Infectious Disease Research Center, Korea Research Institute of Bioscience & Biotechnology, Daejeon, 34141, South Korea. 2 University of Science and Technology (UST), Daejeon, 34113, South Korea. 3 Chungbuk National University, Cheongju, 28644, South Korea. 4 Korea Institute of Environment Ecology, Daejeon, 34016, South Korea. 5 Infectious Disease Research Center, Korea Research Institute of Bioscience & Biotechnology, Daejeon, 34141, South Korea. dgjeong@kribb.re.kr. 6 University of Science and Technology (UST), Daejeon, 34113, South Korea. dgjeong@kribb.re.kr. 7 Infectious Disease Research Center, Korea Research Institute of Bioscience & Biotechnology, Daejeon, 34141, South Korea. syoon@kribb.re.kr. 8 University of Science and Technology (UST), Daejeon, 34113, South Korea. syoon@kribb.re.kr.

    Abstract

    Aquatic birds are known to be a reservoir for the most common influenza A viruses (IAVs). In the annual surveillance program, we collected the feces of migratory birds for the detection of IAVs in South Korea in November 2016. A novel reassorted H3N3 avian influenza virus (AIV) containing genes from viruses of wild and domestic birds was identified and named A/aquatic bird/South Korea/sw006/2016(H3N3). The polymerase basic 2 (PB2) and non-structural (NS) genes of this isolate are most closely related to those of wild-bird-origin AIV, while the polymerase basic 1 (PB1), polymerase acidic (PA), hemagglutinin (HA), nucleoprotein (NP), neuraminidase (NA), and matrix (M) genes are most closely related to those of domestic-bird-origin AIV. A/aquatic bird/South Korea/sw006/2016 contains PA, NP, M, and NS genes were most closely related to those of AIV subtype H4 and PB2, PB1, and HA genes that are most closely related to those of AIV subtype H3N8, while the NA gene was most closely related to those of subtype H10, which was recently detected in humans in China. These results suggest that novel reassortment of AIV strains occurred due to interaction between wild and domestic birds. Hence, we emphasize the need for continued surveillance of avian influenza virus in bird populations.


    PMID: 31456087 DOI: 10.1007/s00705-019-04386-8
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