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Isolation of a Novel Reassortant Highly Pathogenic Avian Influenza (H5N2) Virus in Egypt

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  • Isolation of a Novel Reassortant Highly Pathogenic Avian Influenza (H5N2) Virus in Egypt

    Viruses. 2019 Jun 18;11(6). pii: E565. doi: 10.3390/v11060565.
    Isolation of a Novel Reassortant Highly Pathogenic Avian Influenza (H5N2) Virus in Egypt.

    Hagag NM1, Erfan AM2, El-Husseiny M3, Shalaby AG4, Saif MA5, Tawakol MM6, Nour AA7, Selim AA8, Arafa AS9, Hassan MK10, Hassan WMM11, Fahmy HA12, Ibraheem E13, Attia M14, Abdelhakim AMM15, Shahein MA16, Naguib MM17,18.
    Author information

    Abstract

    Highly pathogenic avian influenza (HPAI) H5N1 and H5N8 have become endemic among domestic poultry in Egypt since 2006 and 2016, respectively. In parallel, the low pathogenic avian influenza H9N2 virus has been endemic since 2010. Despite the continuous circulation of these subtypes for several years, no natural reassortant has been detected so far among the domestic poultry population in Egypt. In this study, the HPAI (H5N2) virus was isolated from a commercial duck farm, giving evidence of the emergence of the first natural reassortment event in domestic poultry in Egypt. The virus was derived as a result of genetic reassortment between avian influenza viruses of H5N8 and H9N2 subtypes circulating in Egypt. The exchange of the neuraminidase segment and high number of acquired mutations might be associated with an alteration in the biological propensities of this virus.


    KEYWORDS:

    Avian influenza; Egypt; H5N2; H5N8; H9N2; poultry; reassortment

    PMID: 31216712 DOI: 10.3390/v11060565
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