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Etiology and characteristics of community-acquired pneumonia in an influenza epidemic period

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  • Etiology and characteristics of community-acquired pneumonia in an influenza epidemic period

    Comp Immunol Microbiol Infect Dis. 2019 Jun;64:153-158. doi: 10.1016/j.cimid.2019.03.004. Epub 2019 Mar 8.
    Etiology and characteristics of community-acquired pneumonia in an influenza epidemic period.

    Lin C1, Chen H2, He P3, Li Y4, Ke C5, Jiao X6.
    Author information

    Abstract

    PURPOSE:

    The etiology of community-acquired pneumonia (CAP) in hospital patients is often ambiguous due to the limited pathogen detection. Lack of a microbiological diagnosis impairs precision treatment in CAP.
    METHODS:

    Specimens collected from the lower respiratory tract of 195 CAP patients, viruses were measured by the Single-plex real-time PCR assay and the conventional culture method was exploited for bacteria.
    RESULTS:

    Among the 195 patients, there were 46 (23.59%) pure bacterial infections, 20 (10.26%) yeast infections, 32 (16.41%) pure viral infections, 8 (4.10%) viral-yeast co-infections, and 17 (8.72%) viral-bacterial co-infections. The two most abundant bacteria were Acinetobacter baumannii and klebsiella pneumoniae, whereas the most common virus was influenza A.
    CONCLUSIONS:

    Non-influenza respiratory microorganisms frequently co-circulated during the epidemic peaks of influenza, which easily being ignored in CAP therapy. In patients with bacterial and viral co-infections, identifying the etiologic agent is crucial for patient's therapy.
    Copyright 2019 Elsevier Ltd. All rights reserved.


    KEYWORDS:

    Co-infections; Community-acquired pneumonia; Influenza; Respiratory virus; bacterial/Yeast infection

    PMID: 31174691 DOI: 10.1016/j.cimid.2019.03.004
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