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Clin Microbiol Infect. 2019 Apr 17. pii: S1198-743X(19)30183-1. doi: 10.1016/j.cmi.2019.04.012. [Epub ahead of print]
Respiratory virus infection amongst hospitalized adult patients with or without clinically-apparent respiratory infection: a prospective cohort study.
To KKW1, Chan KH2, Ho J2, Pang PKP2, Ho DTY2, Chang ACH3, Seng CW3, Yip CCY4, Cheng VCC4, **** IFN5, Yuen KY6.
Author information
Abstract
OBJECTIVES:
We aimed to determine the viral epidemiology and clinical characteristics of patients with and those without clinically-apparent respiratory tract infection.
METHODS:
This prospective cohort study was conducted during the 2018 winter influenza season. Adult patients with fever/respiratory symptoms (fever/RS group) were age- and sex-matched with patients without fever/respiratory symptoms (non-fever/RS group) in a 1:1 ratio. Respiratory viruses were tested using NxTAGTM Respiratory Pathogen Panel IVD, a commercially-available multiplex PCR panel.
RESULTS:
A total of 214 acutely hospitalized patients were included in the final analysis, consisting of 107 with fever/respiratory symptoms (fever/RS group), and 107 age- and sex-matched patients without fever/respiratory symptoms (non-fever/RS group). Respiratory viruses were detected in 34.1% (73/214) of patients, and coinfection occurred in 7.9% (17/214) of patients. The incidence of respiratory virus was higher in the fever/RS group than that in the non-fever/RS group (44.9% [48/107] vs 23.4% [25/107], P=0.001). Influenza B virus, enterovirus/rhinovirus and coronaviruses were detected more frequently in the fever/RS group, while parainfluenza virus 4B and adenovirus were detected more frequently in the non-fever/RS group. Among the non-fever/RS group, chest discomfort was more common among patients tested positive for respiratory viruses than those without respiratory virus detected (44% [11/25] vs 22% [18/82], P=0.04).
CONCLUSIONS:
Respiratory viruses can be frequently detected among hospitalized patients without typical features of respiratory tract infection. These patients may be a source of nosocomial outbreaks.
Copyright ? 2019 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
Adenovirus; Cardiac complications; Influenza; Parainfluenza virus; Respiratory tract infection
PMID: 31004768 DOI: 10.1016/j.cmi.2019.04.012
Respiratory virus infection amongst hospitalized adult patients with or without clinically-apparent respiratory infection: a prospective cohort study.
To KKW1, Chan KH2, Ho J2, Pang PKP2, Ho DTY2, Chang ACH3, Seng CW3, Yip CCY4, Cheng VCC4, **** IFN5, Yuen KY6.
Author information
Abstract
OBJECTIVES:
We aimed to determine the viral epidemiology and clinical characteristics of patients with and those without clinically-apparent respiratory tract infection.
METHODS:
This prospective cohort study was conducted during the 2018 winter influenza season. Adult patients with fever/respiratory symptoms (fever/RS group) were age- and sex-matched with patients without fever/respiratory symptoms (non-fever/RS group) in a 1:1 ratio. Respiratory viruses were tested using NxTAGTM Respiratory Pathogen Panel IVD, a commercially-available multiplex PCR panel.
RESULTS:
A total of 214 acutely hospitalized patients were included in the final analysis, consisting of 107 with fever/respiratory symptoms (fever/RS group), and 107 age- and sex-matched patients without fever/respiratory symptoms (non-fever/RS group). Respiratory viruses were detected in 34.1% (73/214) of patients, and coinfection occurred in 7.9% (17/214) of patients. The incidence of respiratory virus was higher in the fever/RS group than that in the non-fever/RS group (44.9% [48/107] vs 23.4% [25/107], P=0.001). Influenza B virus, enterovirus/rhinovirus and coronaviruses were detected more frequently in the fever/RS group, while parainfluenza virus 4B and adenovirus were detected more frequently in the non-fever/RS group. Among the non-fever/RS group, chest discomfort was more common among patients tested positive for respiratory viruses than those without respiratory virus detected (44% [11/25] vs 22% [18/82], P=0.04).
CONCLUSIONS:
Respiratory viruses can be frequently detected among hospitalized patients without typical features of respiratory tract infection. These patients may be a source of nosocomial outbreaks.
Copyright ? 2019 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
Adenovirus; Cardiac complications; Influenza; Parainfluenza virus; Respiratory tract infection
PMID: 31004768 DOI: 10.1016/j.cmi.2019.04.012