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Virology. 2019 Jan 15;530:11-18. doi: 10.1016/j.virol.2019.01.016. [Epub ahead of print]
Different pathogenicity of two strains of clade 2.3.4.4c H5N6 highly pathogenic avian influenza viruses bearing different PA and NS gene in domestic ducks.
Kwon JH1, Noh JY1, Jeong JH1, Jeong S1, Lee SH1, Kim YJ1, Yuk SS1, Lee DH2, Bae YC3, Park SC3, Lee KH3, Lee EK3, Lee YN3, Lee YJ3, Song CS4.
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Abstract
H5Nx clade 2.3.4.4 highly pathogenic avian influenza viruses (HPAIVs) have been disseminated to wide geographic regions since 2014. In 2016, five distinct genotypes (C-1 to C-5) of clade 2.3.4.4c H5N6 HPAIVs were detected in South Korea. In this study, we evaluated the pathogenicity, susceptibility to infection, and transmissibility of the two strains representing the C-1 and C-4 genotypes of the H5N6 viruses, which have different PA and NS gene, in domestic ducks. Although the susceptibility to infection of domestic ducks to the two strains was similar, the C-4 genotype virus induced higher mortality in ducks than C-1 genotype virus. A higher titer of viral shedding were detected in ducks challenged with the C-4 genotype virus compared with the C-1 genotype virus. These results indicated that the reassortment of HPAIVs with prevailing low pathogenic avian influenza viruses could effect on the pathogenicity in ducks.
Copyright ? 2019. Published by Elsevier Inc.
KEYWORDS:
Domestic duck; H5N6; Highly pathogenic avian influenza virus; Pathogenicity; Reassortment
PMID: 30753976 DOI: 10.1016/j.virol.2019.01.016
Different pathogenicity of two strains of clade 2.3.4.4c H5N6 highly pathogenic avian influenza viruses bearing different PA and NS gene in domestic ducks.
Kwon JH1, Noh JY1, Jeong JH1, Jeong S1, Lee SH1, Kim YJ1, Yuk SS1, Lee DH2, Bae YC3, Park SC3, Lee KH3, Lee EK3, Lee YN3, Lee YJ3, Song CS4.
Author information
Abstract
H5Nx clade 2.3.4.4 highly pathogenic avian influenza viruses (HPAIVs) have been disseminated to wide geographic regions since 2014. In 2016, five distinct genotypes (C-1 to C-5) of clade 2.3.4.4c H5N6 HPAIVs were detected in South Korea. In this study, we evaluated the pathogenicity, susceptibility to infection, and transmissibility of the two strains representing the C-1 and C-4 genotypes of the H5N6 viruses, which have different PA and NS gene, in domestic ducks. Although the susceptibility to infection of domestic ducks to the two strains was similar, the C-4 genotype virus induced higher mortality in ducks than C-1 genotype virus. A higher titer of viral shedding were detected in ducks challenged with the C-4 genotype virus compared with the C-1 genotype virus. These results indicated that the reassortment of HPAIVs with prevailing low pathogenic avian influenza viruses could effect on the pathogenicity in ducks.
Copyright ? 2019. Published by Elsevier Inc.
KEYWORDS:
Domestic duck; H5N6; Highly pathogenic avian influenza virus; Pathogenicity; Reassortment
PMID: 30753976 DOI: 10.1016/j.virol.2019.01.016