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Genetic and antigenic dynamics of influenza A viruses of swine on pig farms in Thailand

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  • Genetic and antigenic dynamics of influenza A viruses of swine on pig farms in Thailand

    Arch Virol. 2018 Nov 10. doi: 10.1007/s00705-018-4091-4. [Epub ahead of print]
    Genetic and antigenic dynamics of influenza A viruses of swine on pig farms in Thailand.

    Mine J1,2, Abe H1,2, Parchariyanon S3, Boonpornprasert P3, Ubonyaem N3, Nuansrichay B3, Takemae N1,2, Tanikawa T1,2, Tsunekuni R1,2, Uchida Y1,2, Saito T4,5.
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    Abstract

    Surveillance studies of influenza A virus of swine (IAV-S) have accumulated information regarding IAVs-S circulating in Thailand, but how IAVs-S evolve within a farm remains unclear. In the present study, we isolated 82 A(H1N1)pdm09 and 87 H3N2 viruses from four farms from 2011 through 2017. We then phylogenetically and antigenically analyzed the isolates to elucidate their evolution within each farm. Phylogenetic analysis demonstrated multiple introductions of A(H1N1)pdm09 viruses that resembled epidemic A(H1N1)pdm09 strains in humans in Thailand, and they reassorted with H3N2 viruses as well as other A(H1N1)pdm09 viruses. Antigenic analysis revealed that the viruses had acquired antigenic diversity either by accumulating substitutions in the hemagglutinin protein or through the introduction of IAV-S strains with different antigenicity. Our results, obtained through continuous longitudinal surveillance, revealed that IAV-S can be maintained on a pig farm over several years through the generation of antigenic diversity due to the accumulation of mutations, introduction of new strains, and reassortment events.


    PMID: 30415389 DOI: 10.1007/s00705-018-4091-4
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