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Isolation and genetic characterization of H13N8 low pathogenic avian influenza virus from migratory birds in eastern China

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  • Isolation and genetic characterization of H13N8 low pathogenic avian influenza virus from migratory birds in eastern China

    Transbound Emerg Dis. 2018 Oct 6. doi: 10.1111/tbed.13035. [Epub ahead of print]
    Isolation and genetic characterization of H13N8 low pathogenic avian influenza virus from migratory birds in eastern China.

    Yu Z1, Gao Y2,3, He H4, Zhao Y2, Yuan X1, Cheng K5.
    Author information

    Abstract

    Low pathogenic avian influenza virus (LPAIV) is an important zoonotic pathogen. Migratory birds are the natural reservoir for all 16 haemagglutinin (HA) and 9 neuraminidase (NA) subtypes of LPAIV. Surveillance of LPAIV in migratory waterfowl and poultry is important for animal and public health. An understanding of the ecology and epidemiology of LPAI viruses in their reservoirs is beneficial for routine surveillance projects. Here, we report the isolation of an H13N8 LPAIV from black-tailed gulls in eastern China. Full genome sequences of this isolate were determined. Genetic analysis of the HA and NA segments of this isolate showed that this H13N8 LPAIV was derived from the Eurasian lineage. Additionally, we speculate that this H13N8 LPAIV was a reassortant between the North American and Eurasian lineages. Interestingly, we identified amino acid motifs responsible for increased virulence or transmission of influenza viruses in mammals. We also found weak but measurable hemagglutination inhibition antibody titers against H13N8 virus in serum samples collected from chickens. These results suggest that continued surveillance for LPAI viruses in migratory birds and poultry is required. This article is protected by copyright. All rights reserved.


    KEYWORDS:

    H13N8; black-tailed gull; chicken; low pathogenic avian influenza virus; migratory birds; poultry

    PMID: 30291732 DOI: 10.1111/tbed.13035
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