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Influenza A(H5N1) viruses with A(H9N2) single gene (matrix or PB1) reassortment isolated from Cambodian live bird markets

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  • Influenza A(H5N1) viruses with A(H9N2) single gene (matrix or PB1) reassortment isolated from Cambodian live bird markets

    Virology. 2018 Jul 31;523:22-26. doi: 10.1016/j.virol.2018.07.028. [Epub ahead of print]
    Influenza A(H5N1) viruses with A(H9N2) single gene (matrix or PB1) reassortment isolated from Cambodian live bird markets.

    Suttie A1, Karlsson EA2, Deng YM3, Horm SV2, Yann S2, Tok S2, Sorn S4, Holl D4, Tum S5, Hurt AC3, Greenhill AR6, Barr IG3, Horwood PF7, Dussart P8.
    Author information

    Abstract

    Live bird market surveillance for avian influenza viruses in Cambodia in 2015 has led to the detection of two 7:1 reassortant influenza A(H5N1) clade 2.3.2.1c viruses. These reassortant strains, designated A/duck/Cambodia/Z564W35M1/2015 and A/chicken/Cambodia/Z850W49M1/2015, both contained a single gene (PB1 and matrix gene, respectively) from concurrently circulating A(H9N2) influenza viruses. All other viral genes from both isolates clustered with A(H5N1) clade 2.3.2.1 viruses. Continued and prolonged co-circulation of influenza A(H5N1) and A(H9N2) viruses in Cambodian live bird markets may present a risk for the emergence of novel influenza reassortant viruses with negative agricultural and/or public health implications.


    KEYWORDS:

    A(H5N1); A(H9N2); Cambodia; Influenza; Live bird markets; Reassortment

    PMID: 30075357 DOI: 10.1016/j.virol.2018.07.028
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