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Sci Rep. 2018 Jul 16;8(1):10693. doi: 10.1038/s41598-018-29079-1.
Genetic characterization and pathogenic potential of H10 avian influenza viruses isolated from live poultry markets in Bangladesh.
El-Shesheny R1,2, Franks J1, Marathe BM1, Hasan MK3, Feeroz MM3, Krauss S1, Vogel P4, McKenzie P1, Webby RJ1, Webster RG5.
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Abstract
Fatal human cases of avian-origin H10N8 influenza virus infections have raised concern about their potential for human-to-human transmission. H10 subtype avian influenza viruses (AIVs) have been isolated from wild and domestic aquatic birds across Eurasia and North America. We isolated eight H10 AIVs (four H10N7, two H10N9, one H10N1, and one H10N6) from live poultry markets in Bangladesh. Genetic analyses demonstrated that all eight isolates belong to the Eurasian lineage. HA phylogenetic and antigenic analyses indicated that two antigenically distinct groups of H10 AIVs are circulating in Bangladeshi live poultry markets. We evaluated the virulence of four representative H10 AIV strains in DBA/2J mice and found that they replicated efficiently in mice without prior adaptation. Moreover, H10N6 and H10N1 AIVs caused high mortality with systemic dissemination. These results indicate that H10 AIVs pose a potential threat to human health and the mechanisms of their transmissibility should be elucidated.
PMID: 30013138 PMCID: PMC6048039 DOI: 10.1038/s41598-018-29079-1
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Genetic characterization and pathogenic potential of H10 avian influenza viruses isolated from live poultry markets in Bangladesh.
El-Shesheny R1,2, Franks J1, Marathe BM1, Hasan MK3, Feeroz MM3, Krauss S1, Vogel P4, McKenzie P1, Webby RJ1, Webster RG5.
Author information
Abstract
Fatal human cases of avian-origin H10N8 influenza virus infections have raised concern about their potential for human-to-human transmission. H10 subtype avian influenza viruses (AIVs) have been isolated from wild and domestic aquatic birds across Eurasia and North America. We isolated eight H10 AIVs (four H10N7, two H10N9, one H10N1, and one H10N6) from live poultry markets in Bangladesh. Genetic analyses demonstrated that all eight isolates belong to the Eurasian lineage. HA phylogenetic and antigenic analyses indicated that two antigenically distinct groups of H10 AIVs are circulating in Bangladeshi live poultry markets. We evaluated the virulence of four representative H10 AIV strains in DBA/2J mice and found that they replicated efficiently in mice without prior adaptation. Moreover, H10N6 and H10N1 AIVs caused high mortality with systemic dissemination. These results indicate that H10 AIVs pose a potential threat to human health and the mechanisms of their transmissibility should be elucidated.
PMID: 30013138 PMCID: PMC6048039 DOI: 10.1038/s41598-018-29079-1
Free full text