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Emerg Microbes Infect. 2018 Jul 2;7(1):123. doi: 10.1038/s41426-018-0109-y.
Swine influenza viruses in Northern Vietnam in 2013-2014.
Baudon E1,2, Chu DKW1, Tung DD3, Thi Nga P3, Vu Mai Phuong H4, Le Khanh Hang N4, Thanh LT4, Thuy NT4, Khanh NC4, Mai LQ4, Khong NV3, Cowling BJ1, Peyre M2, Peiris M5.
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Abstract
Swine are an important intermediate host for emergence of pandemic influenza. Vietnam is the largest swine producer in South East Asia. Systematic virological and serological surveillance of swine influenza viruses was carried out in Northern Vietnam from May 2013 to June 2014 with monthly sampling of pigs in local and large collective slaughterhouses and in a live pig market. Influenza A seroprevalence in the local slaughterhouses and in the large collective slaughterhouse was 48.7% and 29.1%, respectively. Seventy-seven influenza A viruses were isolated, all from the large collective slaughterhouse. Genetic analysis revealed six virus genotypes including H1N1 2009 pandemic (H1N1pdm09) viruses, H1N2 with H1 of human origin, H3N2 and H1N1pdm09 reassortants, and triple-reassortant H3N2 viruses. Phylogenetic analysis of swine and human H1N1pdm09 viruses showed evidence of repeated spill-over from humans to swine rather than the establishment of H1N1pdm09 as long-term distinct lineage in swine. Surveillance at the large collective slaughterhouse proved to be the most efficient, cost-effective, and sustainable method of surveillance for swine influenza viruses in Vietnam.
PMID: 29967457 PMCID: PMC6028489 DOI: 10.1038/s41426-018-0109-y
Free PMC Article
Swine influenza viruses in Northern Vietnam in 2013-2014.
Baudon E1,2, Chu DKW1, Tung DD3, Thi Nga P3, Vu Mai Phuong H4, Le Khanh Hang N4, Thanh LT4, Thuy NT4, Khanh NC4, Mai LQ4, Khong NV3, Cowling BJ1, Peyre M2, Peiris M5.
Author information
Abstract
Swine are an important intermediate host for emergence of pandemic influenza. Vietnam is the largest swine producer in South East Asia. Systematic virological and serological surveillance of swine influenza viruses was carried out in Northern Vietnam from May 2013 to June 2014 with monthly sampling of pigs in local and large collective slaughterhouses and in a live pig market. Influenza A seroprevalence in the local slaughterhouses and in the large collective slaughterhouse was 48.7% and 29.1%, respectively. Seventy-seven influenza A viruses were isolated, all from the large collective slaughterhouse. Genetic analysis revealed six virus genotypes including H1N1 2009 pandemic (H1N1pdm09) viruses, H1N2 with H1 of human origin, H3N2 and H1N1pdm09 reassortants, and triple-reassortant H3N2 viruses. Phylogenetic analysis of swine and human H1N1pdm09 viruses showed evidence of repeated spill-over from humans to swine rather than the establishment of H1N1pdm09 as long-term distinct lineage in swine. Surveillance at the large collective slaughterhouse proved to be the most efficient, cost-effective, and sustainable method of surveillance for swine influenza viruses in Vietnam.
PMID: 29967457 PMCID: PMC6028489 DOI: 10.1038/s41426-018-0109-y
Free PMC Article