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Novel triple-reassortant influenza viruses in pigs, Guangxi, China

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  • Novel triple-reassortant influenza viruses in pigs, Guangxi, China

    Emerg Microbes Infect. 2018 May 16;7(1):85. doi: 10.1038/s41426-018-0088-z.
    Novel triple-reassortant influenza viruses in pigs, Guangxi, China.

    He P1, Wang G2, Mo Y1, Yu Q1, Xiao X1, Yang W1, Zhao W1, Guo X3, Chen Q4, He J1, Liang M1, Zhu J1, Ding Y1, Wei Z1, Ouyang K1, Liu F1, Jian H1, Huang W1, Garc?a-Sastre A5,6,7, Chen Y8.
    Author information

    Abstract

    Considered a "mixing vessel" for influenza viruses, pigs can give rise to new influenza virus reassortants that can threaten humans. During our surveillance of pigs in Guangxi, China from 2013 to 2015, we isolated 11 H1N1 and three H3N2 influenza A viruses of swine origin (IAVs-S). Out of the 14, we detected ten novel triple-reassortant viruses, which contained surface genes (hemagglutinin and neuraminidase) from Eurasian avian-like (EA) H1N1 or seasonal human-like H3N2, matrix (M) genes from H1N1/2009 pandemic or EA H1N1, nonstructural (NS) genes from classical swine, and the remaining genes from H1N1/2009 pandemic. Mouse studies indicate that these IAVs-S replicate efficiently without prior adaptation, with some isolates demonstrating lethality. Notably, the reassortant EA H1N1 viruses with EA-like M gene have been reported in human infections. Further investigations will help to assess the potential risk of these novel triple-reassortant viruses to humans.


    PMID: 29765037 PMCID: PMC5953969 DOI: 10.1038/s41426-018-0088-z
    Free PMC Article
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