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Emerg Micr Infect. Novel triple-reassortant influenza viruses in pigs, Guangxi, China

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  • Emerg Micr Infect. Novel triple-reassortant influenza viruses in pigs, Guangxi, China

    Novel triple-reassortant influenza viruses in pigs, Guangxi, China

    • Emerging Microbes & Infectionsvolume 7, Article number: 85 (2018)
    • doi:10.1038/s41426-018-0088-z
    • Download Citation

    Received: 01 December 2017 Revised: 10 February 2018 Accepted: 12 April 2018 Published: 16 May 2018


    Abstract

    Considered a “mixing vessel” for influenza viruses, pigs can give rise to new influenza virus reassortants that can threaten humans. During our surveillance of pigs in Guangxi, China from 2013 to 2015, we isolated 11 H1N1 and three H3N2 influenza A viruses of swine origin (IAVs-S). Out of the 14, we detected ten novel triple-reassortant viruses, which contained surface genes (hemagglutinin and neuraminidase) from Eurasian avian-like (EA) H1N1 or seasonal human-like H3N2, matrix (M) genes from H1N1/2009 pandemic or EA H1N1, nonstructural (NS) genes from classical swine, and the remaining genes from H1N1/2009 pandemic. Mouse studies indicate that these IAVs-S replicate efficiently without prior adaptation, with some isolates demonstrating lethality. Notably, the reassortant EA H1N1 viruses with EA-like M gene have been reported in human infections. Further investigations will help to assess the potential risk of these novel triple-reassortant viruses to humans.

    full article


    https://www.nature.com/articles/s41426-018-0088-z


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