Tweet
Am J Trop Med Hyg. 2018 Apr 16. doi: 10.4269/ajtmh.17-0494. [Epub ahead of print]
Burden of Influenza in Less Than 5-Year-Old Children Admitted to Hospital with Pneumonia in Developing and Emerging Countries: A Descriptive, Multicenter Study.
Dananch? C1,2, S?nchez Picot V2, B?net T1,2, Messaoudi M2, Chou M3, Wang J4, Pape JW5, Awasthi S6, Bavdekar A7, Rakoto-Andrianarivelo M8, Sylla M9, Nymadawa P10, Russomando G11, Komurian-Pradel F2, Endtz H12,2, Paranhos-Baccal? G2, Vanhems P1,2, On Behalf Of The Pneumonia Gabriel Network.
Author information
Abstract
This descriptive 4-year study reports the proportion of detection of influenza viruses in less than 5-year-old children hospitalized for pneumonia in eight developing and emerging countries and describes clinical and microbiological characteristics of influenza-related pneumonia cases. Hospitalized children presenting radiologically confirmed pneumonia aged 2-60 months were prospectively enrolled in this observational standardized study. Mean proportion of isolated influenza virus was 9.7% (95% confidence interval: 7.9-11.8%) among 888 pneumonia children analyzed, with moderate heterogeneity between countries-ranging from 6.2% in Cambodia to 18.8% in Haiti. The clinical characteristics of children with influenza-related pneumonia were not substantially different from those of other pneumonia cases. Influenza A H1N1-related pneumonia cases appeared as more severe than pneumonia cases related to other strains of influenza. Streptococcus pneumoniae was detected more often in blood samples from influenza-related cases than in those without detected influenza viruses (19.7% versus 9.5%, P = 0.018). Influenza-related pneumonia is frequent among children less than 5 years old with pneumonia, living in developing and emerging countries. Influenza might be a frequent etiologic agent responsible for pneumonia or a predisposing status factor for pneumococcal-related pneumonia in this population.
PMID: 29663903 DOI: 10.4269/ajtmh.17-0494
Burden of Influenza in Less Than 5-Year-Old Children Admitted to Hospital with Pneumonia in Developing and Emerging Countries: A Descriptive, Multicenter Study.
Dananch? C1,2, S?nchez Picot V2, B?net T1,2, Messaoudi M2, Chou M3, Wang J4, Pape JW5, Awasthi S6, Bavdekar A7, Rakoto-Andrianarivelo M8, Sylla M9, Nymadawa P10, Russomando G11, Komurian-Pradel F2, Endtz H12,2, Paranhos-Baccal? G2, Vanhems P1,2, On Behalf Of The Pneumonia Gabriel Network.
Author information
Abstract
This descriptive 4-year study reports the proportion of detection of influenza viruses in less than 5-year-old children hospitalized for pneumonia in eight developing and emerging countries and describes clinical and microbiological characteristics of influenza-related pneumonia cases. Hospitalized children presenting radiologically confirmed pneumonia aged 2-60 months were prospectively enrolled in this observational standardized study. Mean proportion of isolated influenza virus was 9.7% (95% confidence interval: 7.9-11.8%) among 888 pneumonia children analyzed, with moderate heterogeneity between countries-ranging from 6.2% in Cambodia to 18.8% in Haiti. The clinical characteristics of children with influenza-related pneumonia were not substantially different from those of other pneumonia cases. Influenza A H1N1-related pneumonia cases appeared as more severe than pneumonia cases related to other strains of influenza. Streptococcus pneumoniae was detected more often in blood samples from influenza-related cases than in those without detected influenza viruses (19.7% versus 9.5%, P = 0.018). Influenza-related pneumonia is frequent among children less than 5 years old with pneumonia, living in developing and emerging countries. Influenza might be a frequent etiologic agent responsible for pneumonia or a predisposing status factor for pneumococcal-related pneumonia in this population.
PMID: 29663903 DOI: 10.4269/ajtmh.17-0494