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Transbound Emerg Dis. 2018 Mar 6. doi: 10.1111/tbed.12849. [Epub ahead of print]
Appearance of reassortant European avian-origin H1 influenza A viruses of swine in Vietnam.
Takemae N1,2, Nguyen PT3, Le VT3, Nguyen TN4, To TL5, Nguyen TD5, Pham VP3, Vo HV3, Le QVT3, Do HT5, Nguyen DT4, Uchida Y1,2, Saito T1,2,6.
Author information
Abstract
Three subtypes-H1N1, H1N2 and H3N2-of influenza A viruses of swine (IAVs-S) are currently endemic in swine worldwide, but there is considerable genotypic diversity among each subtype and limited geographical distribution. Through IAVs-S monitoring in Vietnam, two H1N2 influenza A viruses were isolated from healthy pigs in Ba Ria-Vung Tau Province, Southern Vietnam, on 2 December 2016. BLAST and phylogenetic analyses revealed that their HA and NA genes were derived from those of European avian-like H1N2 IAVs-S that contained avian-origin H1 and human-like N2 genes, and were particularly closely related to those of IAVs-S circulating in the Netherlands, Germany or Denmark. In addition, the internal genes of these Vietnamese isolates were derived from human A(H1N1)pdm09 viruses, suggesting that the Vietnamese H1N2 IAVs-S are reassortants between European H1N2 IAVs-S and human A(H1N1)pdm09v. The appearance of European avian-like H1N2 IAVs-S in Vietnam marks their first transmission outside Europe. Our results and statistical analyses of the number of live pigs imported into Vietnam suggest that the European avian-like H1N2 IAVs-S may have been introduced into Vietnam with their hosts through international trade. These findings highlight the importance of quarantining imported pigs to impede the introduction of new IAVs-S.
KEYWORDS:
European influenza A virus of swine; Vietnam; influenza A virus; pig
PMID: 29512309 DOI: 10.1111/tbed.12849
Appearance of reassortant European avian-origin H1 influenza A viruses of swine in Vietnam.
Takemae N1,2, Nguyen PT3, Le VT3, Nguyen TN4, To TL5, Nguyen TD5, Pham VP3, Vo HV3, Le QVT3, Do HT5, Nguyen DT4, Uchida Y1,2, Saito T1,2,6.
Author information
Abstract
Three subtypes-H1N1, H1N2 and H3N2-of influenza A viruses of swine (IAVs-S) are currently endemic in swine worldwide, but there is considerable genotypic diversity among each subtype and limited geographical distribution. Through IAVs-S monitoring in Vietnam, two H1N2 influenza A viruses were isolated from healthy pigs in Ba Ria-Vung Tau Province, Southern Vietnam, on 2 December 2016. BLAST and phylogenetic analyses revealed that their HA and NA genes were derived from those of European avian-like H1N2 IAVs-S that contained avian-origin H1 and human-like N2 genes, and were particularly closely related to those of IAVs-S circulating in the Netherlands, Germany or Denmark. In addition, the internal genes of these Vietnamese isolates were derived from human A(H1N1)pdm09 viruses, suggesting that the Vietnamese H1N2 IAVs-S are reassortants between European H1N2 IAVs-S and human A(H1N1)pdm09v. The appearance of European avian-like H1N2 IAVs-S in Vietnam marks their first transmission outside Europe. Our results and statistical analyses of the number of live pigs imported into Vietnam suggest that the European avian-like H1N2 IAVs-S may have been introduced into Vietnam with their hosts through international trade. These findings highlight the importance of quarantining imported pigs to impede the introduction of new IAVs-S.
KEYWORDS:
European influenza A virus of swine; Vietnam; influenza A virus; pig
PMID: 29512309 DOI: 10.1111/tbed.12849