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Estimating influenza disease burden among pregnant women: Application of self-control method

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  • Estimating influenza disease burden among pregnant women: Application of self-control method

    Vaccine. 2017 Aug 24;35(36):4811-4816. doi: 10.1016/j.vaccine.2017.07.006.
    Estimating influenza disease burden among pregnant women: Application of self-control method.

    Ohfuji S1, Deguchi M2, Tachibana D3, Koyama M3, Takagi T4, Yoshioka T5, Urae A6, Fukushima W7, Hirota Y8; Osaka Pregnant Women Influenza Study Group.
    Author information

    Abstract

    To evaluate influenza disease burden among pregnant women, an epidemiological study using the self-control method was conducted. Study subjects were 12,838 pregnant women who visited collaborating maternity hospitals and clinics in Osaka Prefecture, Japan, before the 2013/14 influenza season. As a study outcome, hospitalization due to respiratory illnesses between the 2010/11 and 2013/14 seasons was collected from each study subject through a baseline survey at the time of recruitment and a second survey after the 2013/14 season. The hospitalization rates during pregnancy and non-pregnancy periods was calculated separately. To compare the hospitalization rate during pregnancy with that during non-pregnancy within the same single study subject, Mantel-Haenzel rate ratios (RRMH) were calculated. During the four seasons examined in this study, nine and 17 subjects were hospitalized due to respiratory illnesses during pregnancy and non-pregnancy periods, respectively. The hospitalization rate was 2.54 per 10,000 woman-months during pregnancy and 1.08 per 10,000 woman-months during non-pregnancy. The RRMH for the hospitalization rate during pregnancy compared with that during non-pregnancy was 4.30 (95% confidence interval, 1.96-9.41). Our results suggest that during the influenza season, pregnant women have a higher risk than non-pregnant women for hospitalization due to respiratory illnesses. The self-control method appears to be an appropriate epidemiological method for evaluating the disease burden of influenza among pregnant women.
    Copyright ? 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.


    KEYWORDS:

    Disease burden; Influenza; Pregnant women; Self-control method

    PMID: 28818474 DOI: 10.1016/j.vaccine.2017.07.006
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