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Sci Rep. 2017 Apr 20;7(1):929. doi: 10.1038/s41598-017-01021-x.
A joint analysis of influenza-associated hospitalizations and mortality in Hong Kong, 1998-2013.
Wu P1, Presanis AM2, Bond HS1, Lau EHY1, Fang VJ1, Cowling BJ3.
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Abstract
Influenza viruses may cause severe human infections leading to hospitalization or death. Linear regression models were fitted to population-based data on hospitalizations and deaths. Surveillance data on influenza virus activity permitted inference on influenza-associated hospitalizations and deaths. The ratios of these estimates were used as a potential indicator of severity. Influenza was associated with 431 (95% CrI: 358-503) respiratory deaths and 12,700 (95% CrI: 11,700-13,700) respiratory hospitalizations per year. Majority of the excess deaths occurred in persons ≥65 y of age. The ratios of deaths to hospitalizations in adults ≥65 y were significantly higher for influenza A(H1N1) and A(H1N1)pdm09 compared to A(H3N2) and B. Substantial disease burden associated with influenza viruses were estimated in Hong Kong particularly among children and elderly in 1998-2013. Infections with influenza A(H1N1) was suggested to be more serious than A(H3N2) in older adults.
PMID: 28428558 DOI: 10.1038/s41598-017-01021-x
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A joint analysis of influenza-associated hospitalizations and mortality in Hong Kong, 1998-2013.
Wu P1, Presanis AM2, Bond HS1, Lau EHY1, Fang VJ1, Cowling BJ3.
Author information
Abstract
Influenza viruses may cause severe human infections leading to hospitalization or death. Linear regression models were fitted to population-based data on hospitalizations and deaths. Surveillance data on influenza virus activity permitted inference on influenza-associated hospitalizations and deaths. The ratios of these estimates were used as a potential indicator of severity. Influenza was associated with 431 (95% CrI: 358-503) respiratory deaths and 12,700 (95% CrI: 11,700-13,700) respiratory hospitalizations per year. Majority of the excess deaths occurred in persons ≥65 y of age. The ratios of deaths to hospitalizations in adults ≥65 y were significantly higher for influenza A(H1N1) and A(H1N1)pdm09 compared to A(H3N2) and B. Substantial disease burden associated with influenza viruses were estimated in Hong Kong particularly among children and elderly in 1998-2013. Infections with influenza A(H1N1) was suggested to be more serious than A(H3N2) in older adults.
PMID: 28428558 DOI: 10.1038/s41598-017-01021-x
Free full text