Tweet
Int J Infect Dis. 2017 Feb 3. pii: S1201-9712(17)30042-5. doi: 10.1016/j.ijid.2017.01.039. [Epub ahead of print]
Excess mortality associated with influenza after the 2009 H1N1 pandemic in a subtropical Chinese city, 2010-2015.
Liu XX1, Qin G2, Li X1, Zhang J1, Zhao K1, Hu M1, Wang XL3.
Author information
Abstract
OBJECTIVES:
Our study aims to use quasi-Poisson regression model to estimate mortality burden associated with influenza type/subtypes in a subtropical Chinese city, 2010-2015.
METHODS:
Quasi-Poisson models were separately fitted to weekly numbers of deaths for various causes. The exploratory variables were products of weekly proportions of specimens positive for influenza type/subtype and weekly influenza-like illness consultation rates to represent influenza activity. We adjusted for long-term and seasonal trends, absolute humidity and population size as confounding factors in our models. Excess deaths associated with influenza were regarded as the measurement for disease burden of influenza.
RESULTS:
Excess morality for all-cause deaths associated with influenza was 9.9 per 100,000 population in Hefei, of which A(H3N2) had the highest excess mortality rate, followed by A(H1N1) and influenza B virus. The highest excess mortality rate associated with influenza for different causes was consistently found in year 2014 after the 2009 H1N1 pandemic, with the excess mortality rate for all-cause deaths reached 17.47 per 100,000 population. The sex differences in influenza-associated mortality were not statistically significant (P >0.05).
CONCLUSIONS:
The mortality burden of influenza is substantial in Hefei after the 2009 influenza pandemic, while the evidence on sex difference in mortality burden is limited. The severity profile of influenza type/subtype in China needs to be assessed and confirmed in more cities in future studies.
Copyright ? 2017. Published by Elsevier Ltd.
KEYWORDS:
Disease burden; Excess mortality; Influenza; Poisson model
PMID: 28167255 DOI: 10.1016/j.ijid.2017.01.039
[PubMed - as supplied by publisher] Free full text
Excess mortality associated with influenza after the 2009 H1N1 pandemic in a subtropical Chinese city, 2010-2015.
Liu XX1, Qin G2, Li X1, Zhang J1, Zhao K1, Hu M1, Wang XL3.
Author information
Abstract
OBJECTIVES:
Our study aims to use quasi-Poisson regression model to estimate mortality burden associated with influenza type/subtypes in a subtropical Chinese city, 2010-2015.
METHODS:
Quasi-Poisson models were separately fitted to weekly numbers of deaths for various causes. The exploratory variables were products of weekly proportions of specimens positive for influenza type/subtype and weekly influenza-like illness consultation rates to represent influenza activity. We adjusted for long-term and seasonal trends, absolute humidity and population size as confounding factors in our models. Excess deaths associated with influenza were regarded as the measurement for disease burden of influenza.
RESULTS:
Excess morality for all-cause deaths associated with influenza was 9.9 per 100,000 population in Hefei, of which A(H3N2) had the highest excess mortality rate, followed by A(H1N1) and influenza B virus. The highest excess mortality rate associated with influenza for different causes was consistently found in year 2014 after the 2009 H1N1 pandemic, with the excess mortality rate for all-cause deaths reached 17.47 per 100,000 population. The sex differences in influenza-associated mortality were not statistically significant (P >0.05).
CONCLUSIONS:
The mortality burden of influenza is substantial in Hefei after the 2009 influenza pandemic, while the evidence on sex difference in mortality burden is limited. The severity profile of influenza type/subtype in China needs to be assessed and confirmed in more cities in future studies.
Copyright ? 2017. Published by Elsevier Ltd.
KEYWORDS:
Disease burden; Excess mortality; Influenza; Poisson model
PMID: 28167255 DOI: 10.1016/j.ijid.2017.01.039
[PubMed - as supplied by publisher] Free full text