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A novel chimeric Newcastle disease virus vectored vaccine against highly pathogenic avian influenza virus

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  • A novel chimeric Newcastle disease virus vectored vaccine against highly pathogenic avian influenza virus

    Virology. 2017 Jan 19;503:31-36. doi: 10.1016/j.virol.2017.01.006. [Epub ahead of print]
    A novel chimeric Newcastle disease virus vectored vaccine against highly pathogenic avian influenza virus.

    Kim SH1, Paldurai A1, Samal SK2.
    Author information

    Abstract

    Avian influenza (AI) is an economically-important disease of poultry worldwide. The use of vaccines to control AI has increased because of frequent outbreaks of the disease in endemic countries. Newcastle disease virus (NDV) vectored vaccine has shown to be effective in protecting chickens against a highly pathogenic avian influenza virus (HPAIV) infection. However, preexisting antibodies to NDV vector might affect protective efficacy of the vaccine in the field. As an alternative strategy, we evaluated vaccine efficacy of a chimeric NDV vectored vaccine in which the ectodomains of F and HN proteins were replaced by those of avian paramyxovirus serotype-2. The chimeric NDV vector stably expressed the HA protein in vivo, did not cross-react with NDV, was attenuated to be used as a safe vaccine, and provided a partial protection of 1-day-old immunized chickens against HPAIV subtype H5N1challenge, indicating its potential use for early protection of chickens.
    Copyright ? 2017 Elsevier Inc. All rights reserved.


    KEYWORDS:

    Avian influenza virus; Chickens; Newcastle disease virus; Protection; Vaccine

    PMID: 28110247 DOI: 10.1016/j.virol.2017.01.006
    [PubMed - as supplied by publisher]
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