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Virology. 2016 Dec 10;502:13-19. doi: 10.1016/j.virol.2016.12.008. [Epub ahead of print]
Role of H7 hemagglutinin in murine infectivity of influenza viruses following ocular inoculation.
Belser JA1, Sun X2, Creager HM3, Johnson A2, Ridenour C2, Chen LM2, Tumpey TM2, Maines TR2.
Author information
Abstract
H7 subtype influenza viruses have demonstrated an ocular tropism in humans, causing conjunctivitis and not respiratory symptoms in many infected individuals. However, the molecular determinants which confer ocular tropism are still poorly understood. Here, we used a murine model of ocular inoculation to demonstrate that H7 influenza viruses are more likely to cause infection following ocular exposure than are non-H7 subtype viruses. We included investigation regarding the potential role of several properties of influenza viruses with murine infectivity following ocular inoculation, including virus lineage, pathogenicity, and HA cleavage site composition. Furthermore, we examined the potential contribution of internal proteins to murine ocular infectivity. These studies establish a link between H7 subtype viruses and the risk of heightened infectivity in a mammalian species following ocular exposure, and support the development of non-traditional inoculation methods and models to best understand the human risk posed by influenza viruses of all subtypes.
Published by Elsevier Inc.
KEYWORDS:
Conjunctivitis; Influenza; Mouse model; Ocular; Tropism
PMID: 27960109 DOI: 10.1016/j.virol.2016.12.008
[PubMed - as supplied by publisher]
Role of H7 hemagglutinin in murine infectivity of influenza viruses following ocular inoculation.
Belser JA1, Sun X2, Creager HM3, Johnson A2, Ridenour C2, Chen LM2, Tumpey TM2, Maines TR2.
Author information
Abstract
H7 subtype influenza viruses have demonstrated an ocular tropism in humans, causing conjunctivitis and not respiratory symptoms in many infected individuals. However, the molecular determinants which confer ocular tropism are still poorly understood. Here, we used a murine model of ocular inoculation to demonstrate that H7 influenza viruses are more likely to cause infection following ocular exposure than are non-H7 subtype viruses. We included investigation regarding the potential role of several properties of influenza viruses with murine infectivity following ocular inoculation, including virus lineage, pathogenicity, and HA cleavage site composition. Furthermore, we examined the potential contribution of internal proteins to murine ocular infectivity. These studies establish a link between H7 subtype viruses and the risk of heightened infectivity in a mammalian species following ocular exposure, and support the development of non-traditional inoculation methods and models to best understand the human risk posed by influenza viruses of all subtypes.
Published by Elsevier Inc.
KEYWORDS:
Conjunctivitis; Influenza; Mouse model; Ocular; Tropism
PMID: 27960109 DOI: 10.1016/j.virol.2016.12.008
[PubMed - as supplied by publisher]