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Sci Rep. 2016 Sep 28;6:34489. doi: 10.1038/srep34489.
Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks.
Zhang M1,2, Zhang X2, Xu K2, Teng Q2,3, Liu Q2,3, Li X2,3, Yang J2,3, Xu J1, Chen H2,3, Zhang X1, Li Z2,3.
Author information
Abstract
Three H10 subtype avian influenza viruses were isolated from domestic ducks in China, designated as SH602/H10N8, FJ1761/H10N3 and SX3180/H10N7, with an intravenous pathogenicity index (IVPI) of 0.39, 1.60, and 1.27, respectively. These H10 viruses showed a complex pathology pattern in different species, although full genome characterizations of the viruses could not identify any molecular determinant underlying the observed phenotypes. Our findings describe the pathobiology of the three H10 subtype AIVs in chickens, ducks, and mice. FJ1761/H10N3 evolved E627K and Q591K substitutions in the gene encoding the PB2 protein in infected mice with severe lung damage, suggesting that H10 subtype avian influenza viruses are a potential threat to mammals.
PMID: 27678170 DOI: 10.1038/srep34489
[PubMed - as supplied by publisher] Free full text
Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks.
Zhang M1,2, Zhang X2, Xu K2, Teng Q2,3, Liu Q2,3, Li X2,3, Yang J2,3, Xu J1, Chen H2,3, Zhang X1, Li Z2,3.
Author information
Abstract
Three H10 subtype avian influenza viruses were isolated from domestic ducks in China, designated as SH602/H10N8, FJ1761/H10N3 and SX3180/H10N7, with an intravenous pathogenicity index (IVPI) of 0.39, 1.60, and 1.27, respectively. These H10 viruses showed a complex pathology pattern in different species, although full genome characterizations of the viruses could not identify any molecular determinant underlying the observed phenotypes. Our findings describe the pathobiology of the three H10 subtype AIVs in chickens, ducks, and mice. FJ1761/H10N3 evolved E627K and Q591K substitutions in the gene encoding the PB2 protein in infected mice with severe lung damage, suggesting that H10 subtype avian influenza viruses are a potential threat to mammals.
PMID: 27678170 DOI: 10.1038/srep34489
[PubMed - as supplied by publisher] Free full text