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Nucleic Acids Res. 2016 Sep 26. pii: gkw857. [Epub ahead of print]
Influenza Research Database: An integrated bioinformatics resource for influenza virus research.
Zhang Y1, Aevermann BD1, Anderson TK2, Burke DF3, Dauphin G4, Gu Z5, He S5, Kumar S5, Larsen CN6, Lee AJ1, Li X5, Macken C7, Mahaffey C5, Pickett BE1, Reardon B1, Smith T5, Stewart L1, Suloway C5, Sun G6, Tong L5, Vincent AL2, Walters B5, Zaremba S5, Zhao H5, Zhou L5, Zmasek C1, Klem EB5, Scheuermann RH8.
Author information
Abstract
The Influenza Research Database (IRD) is a U.S. National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Bioinformatics Resource Center dedicated to providing bioinformatics support for influenza virus research. IRD facilitates the research and development of vaccines, diagnostics and therapeutics against influenza virus by providing a comprehensive collection of influenza-related data integrated from various sources, a growing suite of analysis and visualization tools for data mining and hypothesis generation, personal workbench spaces for data storage and sharing, and active user community support. Here, we describe the recent improvements in IRD including the use of cloud and high performance computing resources, analysis and visualization of user-provided sequence data with associated metadata, predictions of novel variant proteins, annotations of phenotype-associated sequence markers and their predicted phenotypic effects, hemagglutinin (HA) clade classifications, an automated tool for HA subtype numbering conversion, linkouts to disease event data and the addition of host factor and antiviral drug components. All data and tools are freely available without restriction from the IRD website at https://www.fludb.org.
? The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.
PMID: 27679478 DOI: 10.1093/nar/gkw857
[PubMed - as supplied by publisher] Free full text
Influenza Research Database: An integrated bioinformatics resource for influenza virus research.
Zhang Y1, Aevermann BD1, Anderson TK2, Burke DF3, Dauphin G4, Gu Z5, He S5, Kumar S5, Larsen CN6, Lee AJ1, Li X5, Macken C7, Mahaffey C5, Pickett BE1, Reardon B1, Smith T5, Stewart L1, Suloway C5, Sun G6, Tong L5, Vincent AL2, Walters B5, Zaremba S5, Zhao H5, Zhou L5, Zmasek C1, Klem EB5, Scheuermann RH8.
Author information
Abstract
The Influenza Research Database (IRD) is a U.S. National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Bioinformatics Resource Center dedicated to providing bioinformatics support for influenza virus research. IRD facilitates the research and development of vaccines, diagnostics and therapeutics against influenza virus by providing a comprehensive collection of influenza-related data integrated from various sources, a growing suite of analysis and visualization tools for data mining and hypothesis generation, personal workbench spaces for data storage and sharing, and active user community support. Here, we describe the recent improvements in IRD including the use of cloud and high performance computing resources, analysis and visualization of user-provided sequence data with associated metadata, predictions of novel variant proteins, annotations of phenotype-associated sequence markers and their predicted phenotypic effects, hemagglutinin (HA) clade classifications, an automated tool for HA subtype numbering conversion, linkouts to disease event data and the addition of host factor and antiviral drug components. All data and tools are freely available without restriction from the IRD website at https://www.fludb.org.
? The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.
PMID: 27679478 DOI: 10.1093/nar/gkw857
[PubMed - as supplied by publisher] Free full text