Tweet
J Infect. 2016 Sep 22. pii: S0163-4453(16)30242-0. doi: 10.1016/j.jinf.2016.09.003. [Epub ahead of print]
Respiratory viruses and influenza-like illness: epidemiology and outcomes in children aged 6 months to 10 years in a multi-country population sample.
Taylor S1, Lopez P2, Weckx L3, Borja-Tabora C4, Ulloa-Gutierrez R5, Lazcano-Ponce E6, Kerdpanich A7, Weber MA8, de Los Santos AM9, Tinoco JC10, Safadi MA11, Seng LF12, Mezerville MH5, Faingezicht I5, Cruz-Valdez A6, Feng Y13, Li P14, Durviaux S13, Haars G13, Roy-Ghanta S14, Vaughn DW14, Nolan T15.
Author information
Abstract
BACKGROUND:
Better population data on respiratory viruses in children in tropical and southern hemisphere countries is needed.
METHODS:
The epidemiology of respiratory viruses among healthy children (6 months to <10 years) with influenza-like illness (ILI) was determined in a population sample derived from an influenza vaccine trial (NCT01051661) in 17 centers in eight countries (Australia, South East Asia and Latin America). Active surveillance for ILI was conducted for approximately 1 year (between February 2010 and August 2011), with PCR analysis of nasal and throat swabs.
RESULTS:
6266 children were included, of whom 2421 experienced 3717 ILI episodes. Rhinovirus/enterovirus had the highest prevalence (41.5%), followed by influenza (15.8%), adenovirus (9.8%), parainfluenza and respiratory syncytial virus (RSV) (both 9.7%), coronavirus (5.6%), human metapneumovirus (5.5%) and human bocavirus (HBov) (2.0%). Corresponding incidence per 100 person-years was 29.78, 11.34, 7.03, 6.96, 6.94, 4.00, 3.98 and 1.41. Except for influenza, respiratory virus prevalence declined with age. The incidence of medically-attended ILI associated with viral infection ranged from 1.03 (HBov) to 23.69 (rhinovirus/enterovirus). The percentage of children missing school or daycare ranged from 21.4% (HBov) to 52.1% (influenza).
CONCLUSIONS:
Active surveillance of healthy children provided evidence of respiratory illness burden associated with several viruses, with a substantial burden in older children.
Copyright ? 2016. Published by Elsevier Ltd.
KEYWORDS:
active surveillance; healthy children; incidence; influenza-like illness; prevalence; respiratory viruses
PMID: 27667752 DOI: 10.1016/j.jinf.2016.09.003
[PubMed - as supplied by publisher]
Respiratory viruses and influenza-like illness: epidemiology and outcomes in children aged 6 months to 10 years in a multi-country population sample.
Taylor S1, Lopez P2, Weckx L3, Borja-Tabora C4, Ulloa-Gutierrez R5, Lazcano-Ponce E6, Kerdpanich A7, Weber MA8, de Los Santos AM9, Tinoco JC10, Safadi MA11, Seng LF12, Mezerville MH5, Faingezicht I5, Cruz-Valdez A6, Feng Y13, Li P14, Durviaux S13, Haars G13, Roy-Ghanta S14, Vaughn DW14, Nolan T15.
Author information
Abstract
BACKGROUND:
Better population data on respiratory viruses in children in tropical and southern hemisphere countries is needed.
METHODS:
The epidemiology of respiratory viruses among healthy children (6 months to <10 years) with influenza-like illness (ILI) was determined in a population sample derived from an influenza vaccine trial (NCT01051661) in 17 centers in eight countries (Australia, South East Asia and Latin America). Active surveillance for ILI was conducted for approximately 1 year (between February 2010 and August 2011), with PCR analysis of nasal and throat swabs.
RESULTS:
6266 children were included, of whom 2421 experienced 3717 ILI episodes. Rhinovirus/enterovirus had the highest prevalence (41.5%), followed by influenza (15.8%), adenovirus (9.8%), parainfluenza and respiratory syncytial virus (RSV) (both 9.7%), coronavirus (5.6%), human metapneumovirus (5.5%) and human bocavirus (HBov) (2.0%). Corresponding incidence per 100 person-years was 29.78, 11.34, 7.03, 6.96, 6.94, 4.00, 3.98 and 1.41. Except for influenza, respiratory virus prevalence declined with age. The incidence of medically-attended ILI associated with viral infection ranged from 1.03 (HBov) to 23.69 (rhinovirus/enterovirus). The percentage of children missing school or daycare ranged from 21.4% (HBov) to 52.1% (influenza).
CONCLUSIONS:
Active surveillance of healthy children provided evidence of respiratory illness burden associated with several viruses, with a substantial burden in older children.
Copyright ? 2016. Published by Elsevier Ltd.
KEYWORDS:
active surveillance; healthy children; incidence; influenza-like illness; prevalence; respiratory viruses
PMID: 27667752 DOI: 10.1016/j.jinf.2016.09.003
[PubMed - as supplied by publisher]