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Pediatrics
August 2016
Hospitalization for Influenza A Versus B
Dat Tran, Wendy Vaudry, Dorothy Moore, Julie A. Bettinger, Scott A. Halperin, David W. Scheifele, Taj Jadvji, Liza Lee, Teresa Mersereau, for the members of the Canadian Immunization Monitoring Program Active
Abstract
BACKGROUND: The extent to which influenza A and B infection differs remains uncertain.
METHODS: Using active surveillance data from the Canadian Immunization Monitoring Program Active at 12 pediatric hospitals, we compared clinical characteristics and outcomes of children ≤16 years admitted with laboratory-confirmed influenza B or seasonal influenza A. We also examined factors associated with ICU admission in children hospitalized with influenza B.
RESULTS: Over 8 nonpandemic influenza seasons (2004-2013), we identified 1510 influenza B and 2645 influenza A cases; median ages were 3.9 and 2.0 years, respectively (P < .0001). Compared with influenza A patients, influenza B patients were more likely to have a vaccine-indicated condition (odds ratio [OR] = 1.30; 95% confidence interval [CI] = 1.14?1.47). Symptoms more often associated with influenza B were headache, abdominal pain, and myalgia (P < .0001 for all symptoms after adjustment for age and health status). The proportion of deaths attributable to influenza was significantly greater for influenza B (1.1%) than influenza A (0.4%); adjusted for age and health status, OR was 2.65 (95% CI = 1.18?5.94). A similar adjusted OR was obtained for all-cause mortality (OR = 2.95; 95% CI = 1.34?6.49). Among healthy children with influenza B, age ≥10 years (relative to <6 months) was associated with the greatest odds of ICU admission (OR = 5.79; 95% CI = 1.91?17.57).
CONCLUSIONS: Mortality associated with pediatric influenza B infection was greater than that of influenza A. Among healthy children hosptialized with influenza B, those 10 years and older had a significant risk of ICU admission.
August 2016
Hospitalization for Influenza A Versus B
Dat Tran, Wendy Vaudry, Dorothy Moore, Julie A. Bettinger, Scott A. Halperin, David W. Scheifele, Taj Jadvji, Liza Lee, Teresa Mersereau, for the members of the Canadian Immunization Monitoring Program Active
Abstract
BACKGROUND: The extent to which influenza A and B infection differs remains uncertain.
METHODS: Using active surveillance data from the Canadian Immunization Monitoring Program Active at 12 pediatric hospitals, we compared clinical characteristics and outcomes of children ≤16 years admitted with laboratory-confirmed influenza B or seasonal influenza A. We also examined factors associated with ICU admission in children hospitalized with influenza B.
RESULTS: Over 8 nonpandemic influenza seasons (2004-2013), we identified 1510 influenza B and 2645 influenza A cases; median ages were 3.9 and 2.0 years, respectively (P < .0001). Compared with influenza A patients, influenza B patients were more likely to have a vaccine-indicated condition (odds ratio [OR] = 1.30; 95% confidence interval [CI] = 1.14?1.47). Symptoms more often associated with influenza B were headache, abdominal pain, and myalgia (P < .0001 for all symptoms after adjustment for age and health status). The proportion of deaths attributable to influenza was significantly greater for influenza B (1.1%) than influenza A (0.4%); adjusted for age and health status, OR was 2.65 (95% CI = 1.18?5.94). A similar adjusted OR was obtained for all-cause mortality (OR = 2.95; 95% CI = 1.34?6.49). Among healthy children with influenza B, age ≥10 years (relative to <6 months) was associated with the greatest odds of ICU admission (OR = 5.79; 95% CI = 1.91?17.57).
CONCLUSIONS: Mortality associated with pediatric influenza B infection was greater than that of influenza A. Among healthy children hosptialized with influenza B, those 10 years and older had a significant risk of ICU admission.
- Accepted June 21, 2016.
- Copyright ? 2016 by the American Academy of Pediatrics
