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Acute viral respiratory infections among children in MERS-endemic Riyadh, Saudi Arabia, 2012-2013

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  • Acute viral respiratory infections among children in MERS-endemic Riyadh, Saudi Arabia, 2012-2013

    J Med Virol. 2016 Jul 19. doi: 10.1002/jmv.24632. [Epub ahead of print]
    Acute viral respiratory infections among children in MERS-endemic Riyadh, Saudi Arabia, 2012-2013.

    Fagbo S1, Garbati MA1, Hasan R1, AlShahrani D1, Al-Shehri AM1, AlFawaz T1, Hakawi A1, Wani TA1, Skakni L1.
    Author information

    Abstract

    INTRODUCTION:

    The emergence of the Middle East Respiratory Syndrome (MERS) emergence in Saudi Arabia has intensified focus on Acute Respiratory Infections [ARIs]. This study sought to identify respiratory viruses (RVs) associated with ARIs in children presenting at a tertiary hospital.
    METHODS:

    Children (aged ≤ 13) presenting with ARI between January 2012 and December 2013 tested for 15 RVs using the SeeplexR RV15 kit were retrospectively included. Epidemiological data was retrieved from patient records.
    RESULTS:

    Of the 2235 children tested, 61.5% were ≤1 year with a male: female ratio of 3:2. Viruses were detected in 1364 (61.02%) children, 233(10.4%) having dual infections: these viruses include respiratory syncytial virus RSV) (24%), human rhinovirus (hRV) (19.7%), adenovirus (5.7%), influenza virus (5.3%) and parainfluenzavirus-3 (4.6%). Children aged 9-11 months were most infected (60.9%). Lower respiratory tract infections (55.4 %) were significantly more than upper respiratory tract infection (45.3 %) (P<0.001). Seasonal variation of RV was directly and inversely proportional to relative humidity and temperature, respectively, for non MERS coronaviruses (NL63, 229E and OC43).
    CONCLUSION:

    The study confirms community-acquired RV associated with ARI in children and suggests modulating roles for abiotic factors in RV epidemiology. However, community-based studies are needed to elucidate how these factors locally influence RV epidemiology. This article is protected by copyright. All rights reserved.
    This article is protected by copyright. All rights reserved.


    KEYWORDS:

    MERS-CoV; Respiratory viruses; acute respiratory illness; multiplex molecular testing platform; pediatrics; season

    PMID: 27430485 DOI: 10.1002/jmv.24632
    [PubMed - as supplied by publisher]
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