Announcement

Collapse
No announcement yet.

Outbreak of H5N2 highly pathogenic avian Influenza A virus infection in two commercial layer facilities: lesions and viral antigen distribution

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Outbreak of H5N2 highly pathogenic avian Influenza A virus infection in two commercial layer facilities: lesions and viral antigen distribution

    J Vet Diagn Invest. 2016 Jul 16. pii: 1040638716658929. [Epub ahead of print]
    Outbreak of H5N2 highly pathogenic avian Influenza A virus infection in two commercial layer facilities: lesions and viral antigen distribution.

    Arruda PH1, Stevenson GW2, Killian ML2, Burrough ER2, Gauger PC2, Harmon KM2, Magstadt DR2, Yoon KJ2, Zhang J2, Madson DM2, Pi?eyro P2, Derscheid RJ2, Schwartz KJ2, Cooper VL2, Halbur PG2, Main RG2, Sato Y2, Arruda BL2.
    Author information

    Abstract

    The largest outbreak of highly pathogenic avian Influenza A virus (HPAIV) infection in U.S. history began in December 2014 resulting in the euthanasia of millions of birds and collateral economic consequences to the U.S. poultry industry. We describe 2 cases of H5N2 HPAIV infection in laying hens in Iowa. Following a sharp increase in mortality with minimal clinical signs, 15 dead birds, from 2 unrelated farms, were submitted to the Iowa State University Veterinary Diagnostic Laboratory. Common lesions included diffuse edema and multifocal hemorrhage of the comb, catarrhal exudate in the oropharynx, and multifocal tracheal hemorrhage. Less common lesions included epicardial petechiae, splenic hemorrhage, and pancreatic necrosis. Influenza A virus nucleoprotein was detected by immunohistochemistry in multiple cell types including ependymal cells, the choroid plexus, neurons, respiratory epithelium and macrophages in the lung, cardiac myocytes, endothelial cells, necrotic foci in the spleen, Kupffer cells in the liver, and necrotic acinar cells in the pancreas. Real-time polymerase chain reaction and sequencing confirmed H5N2 HPAIV with molecular characteristics similar to other contemporary U.S. H5N2 HPAIVs in both cases.
    ? 2016 The Author(s).


    KEYWORDS:

    Avian influenza; H5N2; highly pathogenic avian influenza; layers; natural infection

    PMID: 27423731 DOI: 10.1177/1040638716658929
    [PubMed - as supplied by publisher]
Working...
X