Virol Sin. 2016 Jul 7. [Epub ahead of print]
Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds, 2014-2015.
Bi Y1,2,3, Chen J4,5, Zhang Z6, Li M4, Cai T7, Sharshov K5, Susloparov I5, Shestopalov A5, Wong G8, He Y9, Xing Z10, Sun J10, Liu D8, Liu Y11, Liu L11, Liu W8,12, Lei F7,12, Shi W13, Gao GF11,8,12,9.
Author information
Abstract
A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015. Based on the genetic and phylogenetic analyses, the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA, a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin. The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain (A/Alberta/01/2014). Further analysis showed that similar viruses have been circulating in wild birds in China, Russia, Dubai (Western Asia), Bulgaria and Romania (Europe), as well as domestic poultry in some regions of Africa. The affected areas include the Central Asian, East Asian-Australasian, West Asian-East African, and Black Sea/Mediterranean flyways. These results show that the novel Clade 2.3.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds, thus posing a serious threat to wild birds and potentially humans.
KEYWORDS:
Clade 2.3.2.1c; H5N1; highly pathogenic avian influenza virus; migratory birds; outbreak
PMID: 27405930 DOI: 10.1007/s12250-016-3750-4
[PubMed - as supplied by publisher]
Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds, 2014-2015.
Bi Y1,2,3, Chen J4,5, Zhang Z6, Li M4, Cai T7, Sharshov K5, Susloparov I5, Shestopalov A5, Wong G8, He Y9, Xing Z10, Sun J10, Liu D8, Liu Y11, Liu L11, Liu W8,12, Lei F7,12, Shi W13, Gao GF11,8,12,9.
Author information
Abstract
A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015. Based on the genetic and phylogenetic analyses, the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA, a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin. The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain (A/Alberta/01/2014). Further analysis showed that similar viruses have been circulating in wild birds in China, Russia, Dubai (Western Asia), Bulgaria and Romania (Europe), as well as domestic poultry in some regions of Africa. The affected areas include the Central Asian, East Asian-Australasian, West Asian-East African, and Black Sea/Mediterranean flyways. These results show that the novel Clade 2.3.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds, thus posing a serious threat to wild birds and potentially humans.
KEYWORDS:
Clade 2.3.2.1c; H5N1; highly pathogenic avian influenza virus; migratory birds; outbreak
PMID: 27405930 DOI: 10.1007/s12250-016-3750-4
[PubMed - as supplied by publisher]
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