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Respiratory Viruses Associated Hospitalization among Children Aged <5 Years in Bangladesh: 2010-2014

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  • Respiratory Viruses Associated Hospitalization among Children Aged <5 Years in Bangladesh: 2010-2014

    PLoS One. 2016 Feb 3;11(2):e0147982. doi: 10.1371/journal.pone.0147982. eCollection 2016.
    Respiratory Viruses Associated Hospitalization among Children Aged <5 Years in Bangladesh: 2010-2014.

    Homaira N1, Luby SP1,2, Hossain K1, Islam K1, Ahmed M1, Rahman M1, Rahman Z1, Paul RC1, Bhuiyan MU1, Brooks WA1,3, Sohel BM1, Banik KC1, Widdowson MA2, Willby M2, Rahman M4, Bresee J2, Ramirez KS1,2, Azziz-Baumgartner E1,2.
    Author information

    Abstract

    BACKGROUND:

    We combined hospital-based surveillance and health utilization survey data to estimate the incidence of respiratory viral infections associated hospitalization among children aged < 5 years in Bangladesh.
    METHODS:

    Surveillance physicians collected respiratory specimens from children aged <5 years hospitalized with respiratory illness and residing in the primary hospital catchment areas. We tested respiratory specimens for respiratory syncytial virus, parainfluenza viruses, human metapneumovirus, influenza, adenovirus and rhinoviruses using rRT-PCR. During 2013, we conducted a health utilization survey in the primary catchment areas of the hospitals to determine the proportion of all hospitalizations for respiratory illness among children aged <5 years at the surveillance hospitals during the preceding 12 months. We estimated the respiratory virus-specific incidence of hospitalization by dividing the estimated number of hospitalized children with a laboratory confirmed infection with a respiratory virus by the population aged <5 years of the catchment areas and adjusted for the proportion of children who were hospitalized at the surveillance hospitals.
    RESULTS:

    We estimated that the annual incidence per 1000 children (95% CI) of all cause associated respiratory hospitalization was 11.5 (10-12). The incidences per 1000 children (95% CI) per year for respiratory syncytial virus, parainfluenza, adenovirus, human metapneumovirus and influenza infections were 3(2-3), 0.5(0.4-0.8), 0.4 (0.3-0.6), 0.4 (0.3-0.6), and 0.4 (0.3-0.6) respectively. The incidences per 1000 children (95%CI) of rhinovirus-associated infections among hospitalized children were 5 (3-7), 2 (1-3), 1 (0.6-2), and 3 (2-4) in 2010, 2011, 2012 and 2013, respectively.
    CONCLUSION:

    Our data suggest that respiratory viruses are associated with a substantial burden of hospitalization in children aged <5 years in Bangladesh.


    PMID: 26840782 [PubMed - in process]
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