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Sci Rep. 2015 Aug 11;5:12986. doi: 10.1038/srep12986.
Highly Pathogenic Avian Influenza A(H5N1) Virus Struck Migratory Birds in China in 2015.
Bi Y1, Zhang Z2, Liu W3, Yin Y4, Hong J5, Li X6, Wang H7, Wong G8, Chen J9, Li Y10, Ru W10, Gao R10, Liu D3, Liu Y11, Zhou B11, Gao GF12, Shi W2, Lei F13.
Author information
Abstract
Approximately 100 migratory birds, including whooper swans and pochards, were found dead in the Sanmenxia Reservoir Area of China during January 2015. The causative agent behind this outbreak was identified as H5N1 highly pathogenic avian influenza virus (HPAIV). Genetic and phylogenetic analyses revealed that this Sanmenxia H5N1 virus was a novel reassortant, possessing a Clade 2.3.2.1c HA gene and a H9N2-derived PB2 gene. Sanmenxia Clade 2.3.2.1c-like H5N1 viruses possess the closest genetic identity to A/Alberta/01/2014 (H5N1), which recently caused a fatal respiratory infection in Canada with signs of meningoencephalitis, a highly unusual symptom with influenza infections in humans. Furthermore, this virus was shown to be highly pathogenic to both birds and mammals, and demonstrate tropism for the nervous system. Due to the geographical location of Sanmenxia, these novel H5N1 viruses also have the potential to be imported to other regions through the migration of wild birds, similar to the H5N1 outbreak amongst migratory birds in Qinghai Lake during 2005. Therefore, further investigation and monitoring is required to prevent this novel reassortant virus from becoming a new threat to public health.
PMID: 26259704 [PubMed - in process] PMCID: PMC4531313 Free PMC Article
Highly Pathogenic Avian Influenza A(H5N1) Virus Struck Migratory Birds in China in 2015.
Bi Y1, Zhang Z2, Liu W3, Yin Y4, Hong J5, Li X6, Wang H7, Wong G8, Chen J9, Li Y10, Ru W10, Gao R10, Liu D3, Liu Y11, Zhou B11, Gao GF12, Shi W2, Lei F13.
Author information
Abstract
Approximately 100 migratory birds, including whooper swans and pochards, were found dead in the Sanmenxia Reservoir Area of China during January 2015. The causative agent behind this outbreak was identified as H5N1 highly pathogenic avian influenza virus (HPAIV). Genetic and phylogenetic analyses revealed that this Sanmenxia H5N1 virus was a novel reassortant, possessing a Clade 2.3.2.1c HA gene and a H9N2-derived PB2 gene. Sanmenxia Clade 2.3.2.1c-like H5N1 viruses possess the closest genetic identity to A/Alberta/01/2014 (H5N1), which recently caused a fatal respiratory infection in Canada with signs of meningoencephalitis, a highly unusual symptom with influenza infections in humans. Furthermore, this virus was shown to be highly pathogenic to both birds and mammals, and demonstrate tropism for the nervous system. Due to the geographical location of Sanmenxia, these novel H5N1 viruses also have the potential to be imported to other regions through the migration of wild birds, similar to the H5N1 outbreak amongst migratory birds in Qinghai Lake during 2005. Therefore, further investigation and monitoring is required to prevent this novel reassortant virus from becoming a new threat to public health.
PMID: 26259704 [PubMed - in process] PMCID: PMC4531313 Free PMC Article