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J Infect Dis. 2015 Jun 11. pii: jiv330. [Epub ahead of print]
A newly emerged swine origin A(H3N2)v influenza virus dampens host antiviral immunity but induces potent inflammasome activation.
Cao W1, Mishina M2, Ranjan P1, De La Cruz JA2, Kim JH1, Garten R3, Kumar A1, Garc?a-Sastre A4, Katz JM1, Gangappa S1, Sambhara S1.
Author information
Abstract
We compared the innate immune response to newly emerged swine origin H3N2 influenza A variant virus containing the M gene from A(H1N1)pdm09 virus (A(H3N2)vpm), with 2010 swine-origin A(H3N2)v and seasonal A(H3N2) viruses. Our results demonstrated that A(H3N2)vpM virus-induced myeloid dendritic cells secreted significantly lower levels of type I interferon (IFN) but produced significantly higher levels of pro-inflammatory cytokines and induced potent inflammasome activation. The reduction in antiviral immunity with increased inflammatory responses upon A(H3N2)vpM virus infection suggest that these viruses have the potential for increased disease severity in susceptible hosts.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 26068782 [PubMed - as supplied by publisher]
A newly emerged swine origin A(H3N2)v influenza virus dampens host antiviral immunity but induces potent inflammasome activation.
Cao W1, Mishina M2, Ranjan P1, De La Cruz JA2, Kim JH1, Garten R3, Kumar A1, Garc?a-Sastre A4, Katz JM1, Gangappa S1, Sambhara S1.
Author information
Abstract
We compared the innate immune response to newly emerged swine origin H3N2 influenza A variant virus containing the M gene from A(H1N1)pdm09 virus (A(H3N2)vpm), with 2010 swine-origin A(H3N2)v and seasonal A(H3N2) viruses. Our results demonstrated that A(H3N2)vpM virus-induced myeloid dendritic cells secreted significantly lower levels of type I interferon (IFN) but produced significantly higher levels of pro-inflammatory cytokines and induced potent inflammasome activation. The reduction in antiviral immunity with increased inflammatory responses upon A(H3N2)vpM virus infection suggest that these viruses have the potential for increased disease severity in susceptible hosts.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 26068782 [PubMed - as supplied by publisher]