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J Gen Virol. 2015 Apr 22. pii: vir.0.000155. doi: 10.1099/vir.0.000155. [Epub ahead of print]
Influenza A virus evolution and spatio-temporal dynamics in Eurasian Wild Birds: A phylogenetic and phylogeographic study of whole-genome sequence data.
Lewis NS1, Verhagen JH2, Javakhishvili Z3, Russell CA1, Lexmond P2, Westgeest KB2, Bestebroer TM2, Halpin RA4, Lin X4, Ransier A4, Fedorova NB4, Stockwell TB4, Latorre-Margalef N5, Olsen B6, Smith G7, Bahl J7, Wentworth DE4, Waldenstr?m J5, Fouchier RA2, de Graaf M8.
Author information
Abstract
Low pathogenic avian influenza A viruses have a natural host reservoir in wild waterbirds and the potential to spread to other host species. Here we investigate the evolutionary, spatial and temporal dynamics of avian influenza A viruses in Eurasian wild birds. We use whole genome sequences collected as part of an intensive long-term Eurasian wild bird surveillance study and combine this genetic data with temporal and spatial information to explore the virus evolutionary dynamics. Frequent reassortment and co-circulating lineages were observed for all eight genomic RNA segments over time. There was no apparent species-specific effect on the diversity of the avian influenza A viruses. There was a spatial and temporal relationship between the Eurasian sequences and significant viral migration of avian influenza A viruses from West towards Central Asia. The observed viral migration patterns differed between segments. Further we discuss the challenges faced when analysing these surveillance and sequence data and the caveats to be borne in mind when drawing conclusions from the apparent results of such analyses.
PMID: 25904147 [PubMed - as supplied by publisher]
Influenza A virus evolution and spatio-temporal dynamics in Eurasian Wild Birds: A phylogenetic and phylogeographic study of whole-genome sequence data.
Lewis NS1, Verhagen JH2, Javakhishvili Z3, Russell CA1, Lexmond P2, Westgeest KB2, Bestebroer TM2, Halpin RA4, Lin X4, Ransier A4, Fedorova NB4, Stockwell TB4, Latorre-Margalef N5, Olsen B6, Smith G7, Bahl J7, Wentworth DE4, Waldenstr?m J5, Fouchier RA2, de Graaf M8.
Author information
Abstract
Low pathogenic avian influenza A viruses have a natural host reservoir in wild waterbirds and the potential to spread to other host species. Here we investigate the evolutionary, spatial and temporal dynamics of avian influenza A viruses in Eurasian wild birds. We use whole genome sequences collected as part of an intensive long-term Eurasian wild bird surveillance study and combine this genetic data with temporal and spatial information to explore the virus evolutionary dynamics. Frequent reassortment and co-circulating lineages were observed for all eight genomic RNA segments over time. There was no apparent species-specific effect on the diversity of the avian influenza A viruses. There was a spatial and temporal relationship between the Eurasian sequences and significant viral migration of avian influenza A viruses from West towards Central Asia. The observed viral migration patterns differed between segments. Further we discuss the challenges faced when analysing these surveillance and sequence data and the caveats to be borne in mind when drawing conclusions from the apparent results of such analyses.
PMID: 25904147 [PubMed - as supplied by publisher]