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Elife. 2015 Jan 16;4. doi: 10.7554/eLife.05055. [Epub ahead of print]
The contrasting phylodynamics of human influenza B viruses.
Vijaykrishna D1, Holmes EC2, Joseph U1, Fourment M2, Su YC1, Halpin R3, Lee RT4, Deng YM5, Gunalan V4, Lin X3, Stockwell TB3, Fedorova NB3, Zhou B3, Spirason N5, K?hnert D6, Boskova V7, Stadler T8, Costa AM9, Dwyer DE10, Huang QS11, Jennings LC12, Rawlinson W13, Sullivan SG5, Hurt AC5, Maurer-Stroh S4, Wentworth DE3, Smith GJ1, Barr I14.
Author information
Abstract
A complex interplay of viral, host and ecological factors shape the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for influenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of influenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection and receptor binding preference. In sum, this work identifies new factors that are important determinants of influenza B evolution and epidemiology.
KEYWORDS:
antigenic drift; epidemiology; evolution; evolutionary biology; genomics; human; infectious disease; influenza virus; microbiology; viruses
PMID: 25594904 [PubMed - as supplied by publisher] Free full text
The contrasting phylodynamics of human influenza B viruses.
Vijaykrishna D1, Holmes EC2, Joseph U1, Fourment M2, Su YC1, Halpin R3, Lee RT4, Deng YM5, Gunalan V4, Lin X3, Stockwell TB3, Fedorova NB3, Zhou B3, Spirason N5, K?hnert D6, Boskova V7, Stadler T8, Costa AM9, Dwyer DE10, Huang QS11, Jennings LC12, Rawlinson W13, Sullivan SG5, Hurt AC5, Maurer-Stroh S4, Wentworth DE3, Smith GJ1, Barr I14.
Author information
Abstract
A complex interplay of viral, host and ecological factors shape the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for influenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of influenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection and receptor binding preference. In sum, this work identifies new factors that are important determinants of influenza B evolution and epidemiology.
KEYWORDS:
antigenic drift; epidemiology; evolution; evolutionary biology; genomics; human; infectious disease; influenza virus; microbiology; viruses
PMID: 25594904 [PubMed - as supplied by publisher] Free full text