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J Infect Dis. Transmission of Influenza Virus via Aerosols and Fomites in the Guinea Pig Model.

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  • J Infect Dis. Transmission of Influenza Virus via Aerosols and Fomites in the Guinea Pig Model.

    J Infect Dis. 2009 Feb 9. [Epub ahead of print]

    Transmission of Influenza Virus via Aerosols and Fomites in the Guinea Pig Model.

    Mubareka S, Lowen AC, Steel J, Coates AL, Garc?a-Sastre A, Palese P. - 1Department of Microbiology, 2Emerging Pathogens Institute, and 3Department of Medicine, Mount Sinai School of Medicine, New York, New York; 4Division of Respiratory Medicine, Hospital for Sick Children, and Research Institute for Physiology and Experimental Medicine, University of Toronto, Toronto, Ontario, Canada.

    Limited data on the relative contributions of different routes of transmission for influenza virus are available.
    Person-to-person transmission is central to seasonal and pandemic spread; nevertheless, the modes of spread are a matter of ongoing debate.
    Resolution of this discussion is paramount to the development of effective control measures in health care and community settings.
    Using the guinea pig model, we demonstrated that transmission of influenza A/Panama/2007/1999 (H3N2) virus through the air is efficient, compared with spread through contaminated environmental surfaces (fomites).
    We also examined the aerosol transmission efficiencies of 2 human influenza virus A strains and found that A/Panama/2007/1999 influenza virus transmitted more efficiently than A/Texas/36/1991 (H1N1) virus in our model.
    The data provide new and much-needed insights into the modes of influenza virus spread and strain-specific differences in the efficiency of transmission.

    PMID: 19203260 [PubMed - as supplied by publisher]
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