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J Virol. 2014 Jan 15. [Epub ahead of print]
Antigenic Mapping of the Hemagglutinin of an H9N2 Avian Influenza Virus Reveals Novel Critical Amino Acid Positions in Antigenic Sites.
Wan Z, Ye J, Xu L, Shao H, Jin W, Qian K, Wan H, Qin A.
Author information
Abstract
H9N2 influenza virus is undergoing extensive genetic and antigenic evolution, warranting detail antigenic mapping of its hemagglutinin (HA). Through examining antibody escape mutants of an Asian avian H9N2 virus, we identified 9 critical amino acid positions in H9 antigenic sites. Five of these positions, 164, 167, 168, 196 and 207, have not been reported previously, representing novel molecular markers for monitoring the antigenic change of H9N2 virus.
PMID:
24429369
[PubMed - as supplied by publisher]
Antigenic Mapping of the Hemagglutinin of an H9N2 Avian Influenza Virus Reveals Novel Critical Amino Acid Positions in Antigenic Sites.
Wan Z, Ye J, Xu L, Shao H, Jin W, Qian K, Wan H, Qin A.
Author information
Abstract
H9N2 influenza virus is undergoing extensive genetic and antigenic evolution, warranting detail antigenic mapping of its hemagglutinin (HA). Through examining antibody escape mutants of an Asian avian H9N2 virus, we identified 9 critical amino acid positions in H9 antigenic sites. Five of these positions, 164, 167, 168, 196 and 207, have not been reported previously, representing novel molecular markers for monitoring the antigenic change of H9N2 virus.
PMID:
24429369
[PubMed - as supplied by publisher]
