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J Med Virol. 2013 Oct 31. doi: 10.1002/jmv.23829. [Epub ahead of print]
Large scale screening of human sera for HCV RNA and GBV-C RNA.
Keys JR, Leone PA, Eron JJ, Alexander K, Brinson M, Swanstrom R.
Source
University of North Carolina, Chapel Hill, North Carolina.
Abstract
North Carolina locates acute HIV cases by pooled nucleic acid testing of HIV-antibody negative serum samples. Here, 224 pools of 80 HIV-negative samples (N = 17,920) were screened for viral RNA from HCV, GBV-C, and influenza A. No evidence of influenza A was found, but HCV and GBV-C were common (1.2% and 1.7% prevalence, respectively), demonstrating the utility of pooled testing in locating individuals that may remain undiagnosed otherwise. By sequencing positive pools, potential transmission clusters may be located as well. J. Med. Virol. ? 2013 Wiley Periodicals, Inc.
? 2013 Wiley Periodicals, Inc.
KEYWORDS:
GB virus C, acute HIV infection, emerging pathogens, hepatitis C virus, influenza A, public health
PMID:
24178362
[PubMed - as supplied by publisher]
Large scale screening of human sera for HCV RNA and GBV-C RNA.
Keys JR, Leone PA, Eron JJ, Alexander K, Brinson M, Swanstrom R.
Source
University of North Carolina, Chapel Hill, North Carolina.
Abstract
North Carolina locates acute HIV cases by pooled nucleic acid testing of HIV-antibody negative serum samples. Here, 224 pools of 80 HIV-negative samples (N = 17,920) were screened for viral RNA from HCV, GBV-C, and influenza A. No evidence of influenza A was found, but HCV and GBV-C were common (1.2% and 1.7% prevalence, respectively), demonstrating the utility of pooled testing in locating individuals that may remain undiagnosed otherwise. By sequencing positive pools, potential transmission clusters may be located as well. J. Med. Virol. ? 2013 Wiley Periodicals, Inc.
? 2013 Wiley Periodicals, Inc.
KEYWORDS:
GB virus C, acute HIV infection, emerging pathogens, hepatitis C virus, influenza A, public health
PMID:
24178362
[PubMed - as supplied by publisher]
