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Emerg Infect Dis. Seroepidemiologic Study of Pandemic (H1N1) 2009 during Outbreak in Boarding School, England
[Source: Emerging Infectious Diseases Journal, full text: (LINK). Abstract, edited.]
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Volume 17, Number 9?September 2011
Research
Seroepidemiologic Study of Pandemic (H1N1) 2009 during Outbreak in Boarding School, England
Sandra Johnson, Chikwe Ihekweazu, Pia Hardelid, Nika Raphaely, Katja Hoschler, Alison Bermingham, Muhammad Abid, Richard Pebody, Graham Bickler, John Watson, and ?amonn O'Moore
Author affiliations: Health Protection Agency, London, UK (S. Johnson, C. Ihekweazu, P. Hardelid, K. Hoschler, A. Bermingham, R. Pebody, G. Bickler, J. Watson); and Health Protection Agency, Oxfordshire, UK (N. Raphaely, M. Abid, ?. O'Moore)
Abstract
We conducted a seroepidemiologic study during an outbreak of pandemic (H1N1) 2009 in a boarding school in England. Overall, 353 (17%) of students and staff completed a questionnaire and provided a serum sample. The attack rate was 40.5% and 34.1% for self-reported acute respiratory infection (ARI). Staff were less likely to be seropositive than students 13?15 years of age (staff 20?49 years, adjusted odds ratio [AOR] 0.30; >50 years AOR 0.20). Teachers were more likely to be seropositive than other staff (AOR 7.47, 95% confidence interval [CI] 2.31?24.2). Of seropositive persons, 44.6% (95% CI 36.2%?53.3%) did not report ARI. Conversely, of 141 with ARI and 63 with influenza-like illness, 45.8% (95% CI 37.0%?54.0%) and 30.2% (95% CI 19.2%?43.0%) had negative test results, respectively. A weak association was found between seropositivity and a prophylactic dose of antiviral agents (AOR 0.55, 95% CI 0.30?0.99); prophylactic antiviral agents lowered the odds of ARI by 50%.
-Research
Seroepidemiologic Study of Pandemic (H1N1) 2009 during Outbreak in Boarding School, England
Sandra Johnson, Chikwe Ihekweazu, Pia Hardelid, Nika Raphaely, Katja Hoschler, Alison Bermingham, Muhammad Abid, Richard Pebody, Graham Bickler, John Watson, and ?amonn O'Moore
Author affiliations: Health Protection Agency, London, UK (S. Johnson, C. Ihekweazu, P. Hardelid, K. Hoschler, A. Bermingham, R. Pebody, G. Bickler, J. Watson); and Health Protection Agency, Oxfordshire, UK (N. Raphaely, M. Abid, ?. O'Moore)
Abstract
We conducted a seroepidemiologic study during an outbreak of pandemic (H1N1) 2009 in a boarding school in England. Overall, 353 (17%) of students and staff completed a questionnaire and provided a serum sample. The attack rate was 40.5% and 34.1% for self-reported acute respiratory infection (ARI). Staff were less likely to be seropositive than students 13?15 years of age (staff 20?49 years, adjusted odds ratio [AOR] 0.30; >50 years AOR 0.20). Teachers were more likely to be seropositive than other staff (AOR 7.47, 95% confidence interval [CI] 2.31?24.2). Of seropositive persons, 44.6% (95% CI 36.2%?53.3%) did not report ARI. Conversely, of 141 with ARI and 63 with influenza-like illness, 45.8% (95% CI 37.0%?54.0%) and 30.2% (95% CI 19.2%?43.0%) had negative test results, respectively. A weak association was found between seropositivity and a prophylactic dose of antiviral agents (AOR 0.55, 95% CI 0.30?0.99); prophylactic antiviral agents lowered the odds of ARI by 50%.
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