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Euro Surveill. Missed diagnosis of influenza B virus due to nucleoprotein sequence mutations, Singapore, April 2011

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  • Euro Surveill. Missed diagnosis of influenza B virus due to nucleoprotein sequence mutations, Singapore, April 2011

    [Source: Eurosurveillance, full text: (LINK). Abstract, edited.]

    Eurosurveillance, Volume 16, Issue 33, 18 August 2011
    Rapid communications
    Missed diagnosis of influenza B virus due to nucleoprotein sequence mutations, Singapore, April 2011



    H K Lee<SUP>1</SUP>, C K Lee<SUP>1</SUP>, T P Loh<SUP>2</SUP>, D Chiang<SUP>3</SUP>, E S Koay<SUP>1</SUP><SUP>,4</SUP>, J W Tang ()<SUP>1</SUP>
    1. Molecular Diagnosis Centre, Department of Laboratory Medicine, National University Hospital, Singapore
    2. Clinical Chemistry Division, Department of Laboratory Medicine, National University Hospital, Singapore
    3. Microbiology Division, Department of Laboratory Medicine, National University Hospital, Singapore
    4. Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    <HR>
    Citation style for this article: Lee HK, Lee CK, Loh TP, Chiang D, Koay ES, Tang JW. Missed diagnosis of influenza B virus due to nucleoprotein sequence mutations, Singapore, April 2011 . Euro Surveill. 2011;16(33):pii=19943. Available online: http://www.eurosurveillance.org/View...rticleId=19943
    Date of submission: 08 August 2011
    <HR>A new influenza B variant was discovered in Singapore in April 2011 during diagnostic testing of a 3-year-old boy with respiratory symptoms. Influenza B virus was isolated from culture and confirmed by standard immunofluorescence testing, but was not detected by the routine, in-house influenza screening reverse-transcription polymerase chain reaction assay that targets the nucleoprotein (NP) gene. Subsequent sequencing investigations demonstrated that several other published assays targeting NP could also fail to detect this novel variant.
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