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Health Sci Rep
. 2025 Mar 4;8(3):e70458.
doi: 10.1002/hsr2.70458. eCollection 2025 Mar. In-Hospital Death and Risk Factors in Adults With Influenza in Spain (2016-2022): A Cross-Sectional Study With Focus on Older Patients
Jose-Manuel Ramos-Rincon 1 2 , Hector Pinargote-Celorio 3 , Rosario Sanchez-Martinez 1 2 , Juan-Carlos Rodríguez-Diaz 1 4 , Silvia Otero 3 , Fatima Valero-Sempere 2 , Diego Torrús 3 5 , Beatriz Valero-Novella 2 , Geronima Riera 6 , Vicente Boix 1 3 , Esperanza Merino 1 7
Affiliations
Background and aims: Influenza mortality rates varying across different populations. This study aims to assess influenza lethality in hospitalized adults (≥ 15 years) and identify key risk factors according to age.
Methods: We designed a retrospective study at Dr. Balmis General University Hospital (Alicante, Spain), including patients hospitalized for influenza from 2016 to 2022. In-hospital death was expressed as the case fatality rate (CFR). Variables yielding a p value under 0.1 on univariable analysis were included in the multivariable logistic regression model to identify risk factors for lethality.
Results: Of 1613 patients admitted for influenza (incidence 86 per 10,000 admissions), 96 died (CFR 5.95%). Lethality increased with age, reaching 8.4% in patients aged 80-89 years and 19.5% in those over 90. In all of the cohort, risk factors were age, dementia, respiratory failure, influenza pneumonia, and sepsis, while treatment with oseltamivir acted as a protective factor. In patients < 80 years of age, risk factors were neoplasia, respiratory failure, and influenza pneumonia, whereas oseltamivir treatment was a protective factor. In patients 80 years (n = 554; 34.3%), the risk of mortality increased with age, dementia, respiratory failure, noninfluenza pneumonia, and sepsis.
Conclusion: Influenza deaths increase with age; this relationship is accentuated in people aged 80 or older. Respiratory failure was the main risk factor in all patients hospitalized for influenza. Treatment with oseltamivir protected patients (especially those < 80 years) against deaths. Patients < 80 years-old carried a higher risk of death if they had a neoplasia, whereas in ≥ 80 patients, the risk was associated with dementia and noninfluenza pneumonia.
Keywords: aged; influenza; mortality; over 80 and older; respiratory insufficiency.
. 2025 Mar 4;8(3):e70458.
doi: 10.1002/hsr2.70458. eCollection 2025 Mar. In-Hospital Death and Risk Factors in Adults With Influenza in Spain (2016-2022): A Cross-Sectional Study With Focus on Older Patients
Jose-Manuel Ramos-Rincon 1 2 , Hector Pinargote-Celorio 3 , Rosario Sanchez-Martinez 1 2 , Juan-Carlos Rodríguez-Diaz 1 4 , Silvia Otero 3 , Fatima Valero-Sempere 2 , Diego Torrús 3 5 , Beatriz Valero-Novella 2 , Geronima Riera 6 , Vicente Boix 1 3 , Esperanza Merino 1 7
Affiliations
- PMID: 40046094
- PMCID: PMC11879891
- DOI: 10.1002/hsr2.70458
Background and aims: Influenza mortality rates varying across different populations. This study aims to assess influenza lethality in hospitalized adults (≥ 15 years) and identify key risk factors according to age.
Methods: We designed a retrospective study at Dr. Balmis General University Hospital (Alicante, Spain), including patients hospitalized for influenza from 2016 to 2022. In-hospital death was expressed as the case fatality rate (CFR). Variables yielding a p value under 0.1 on univariable analysis were included in the multivariable logistic regression model to identify risk factors for lethality.
Results: Of 1613 patients admitted for influenza (incidence 86 per 10,000 admissions), 96 died (CFR 5.95%). Lethality increased with age, reaching 8.4% in patients aged 80-89 years and 19.5% in those over 90. In all of the cohort, risk factors were age, dementia, respiratory failure, influenza pneumonia, and sepsis, while treatment with oseltamivir acted as a protective factor. In patients < 80 years of age, risk factors were neoplasia, respiratory failure, and influenza pneumonia, whereas oseltamivir treatment was a protective factor. In patients 80 years (n = 554; 34.3%), the risk of mortality increased with age, dementia, respiratory failure, noninfluenza pneumonia, and sepsis.
Conclusion: Influenza deaths increase with age; this relationship is accentuated in people aged 80 or older. Respiratory failure was the main risk factor in all patients hospitalized for influenza. Treatment with oseltamivir protected patients (especially those < 80 years) against deaths. Patients < 80 years-old carried a higher risk of death if they had a neoplasia, whereas in ≥ 80 patients, the risk was associated with dementia and noninfluenza pneumonia.
Keywords: aged; influenza; mortality; over 80 and older; respiratory insufficiency.