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Marshleen Yadav1 ,Sagar Bhayana1, Joseph Liu1, Lanchun Lu1, Jason Huang1, Ya Ma1, Zahida Qamri1, Xiaokui Mo3,
Diviya S. Jacob1, Shashaank T. Parasa1, Noureen Bhuiya1, Paolo Fadda1, Meng Xu-Welliver1,
Arnab Chakravarti1,and Naduparambil K. Jacob1,
See all authors and affiliations
Science Translational Medicine 15 Jul 2020:
Vol. 12, Issue 552, eaaw5831
DOI: 10.1126/scitranslmed.aaw5831
Detecting radiation in a single drop
Practical, scalable approaches for measuring therapeutic or accidental ionizing radiation exposure are needed. Yadav et al. show that the expression of two miRNAs in a drop of blood allowed inference of recent gamma or neutron radiation exposure in a variety of mouse models subjected to fractionated or single acute radiation and patients with leukemia undergoing fractionated radiotherapy within a few hours after blood collection. Although validation in nonhuman primates and testing of mixed-field exposure is needed, this simple two-miRNA assay shows preclinical promise for estimating radiation exposure at a range of doses relevant to clinical and catastrophic radiation exposure in humans.
Diviya S. Jacob1, Shashaank T. Parasa1, Noureen Bhuiya1, Paolo Fadda1, Meng Xu-Welliver1,
Arnab Chakravarti1,and Naduparambil K. Jacob1,
See all authors and affiliations
Science Translational Medicine 15 Jul 2020:
Vol. 12, Issue 552, eaaw5831
DOI: 10.1126/scitranslmed.aaw5831
Detecting radiation in a single drop
Practical, scalable approaches for measuring therapeutic or accidental ionizing radiation exposure are needed. Yadav et al. show that the expression of two miRNAs in a drop of blood allowed inference of recent gamma or neutron radiation exposure in a variety of mouse models subjected to fractionated or single acute radiation and patients with leukemia undergoing fractionated radiotherapy within a few hours after blood collection. Although validation in nonhuman primates and testing of mixed-field exposure is needed, this simple two-miRNA assay shows preclinical promise for estimating radiation exposure at a range of doses relevant to clinical and catastrophic radiation exposure in humans.
