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Hum Vaccin Immunother. 2017 Oct 23:0. doi: 10.1080/21645515.2017.1378292. [Epub ahead of print]
Clinician-initiated Research on Treating the Host Response to Pandemic Influenza.
Fedson DS.
Abstract
To prepare for the next influenza pandemic and other emerging virus diseases, scientists and health officials are focused on developing new vaccines and treatments that target these viruses. Ideally, these interventions could be highly effective, but for many practical reasons these "top down" efforts are unlikely to provide clinicians with what they will need to manage their patients. As a "bottom up" alternative, combinations of generic drugs like statins and angiotensin receptor blockers (ARBs) might be used to treat the host response to infection. These drugs counteract endothelial dysfunction, a central abnormality in these diseases. Observational studies in patients with influenza, pneumonia, sepsis and Ebola suggest they might work.
KEYWORDS:
Ebola; Pandemic influenza; angiotensin receptor blockers; host response; statins
PMID: 29058516 DOI: 10.1080/21645515.2017.1378292
Clinician-initiated Research on Treating the Host Response to Pandemic Influenza.
Fedson DS.
Abstract
To prepare for the next influenza pandemic and other emerging virus diseases, scientists and health officials are focused on developing new vaccines and treatments that target these viruses. Ideally, these interventions could be highly effective, but for many practical reasons these "top down" efforts are unlikely to provide clinicians with what they will need to manage their patients. As a "bottom up" alternative, combinations of generic drugs like statins and angiotensin receptor blockers (ARBs) might be used to treat the host response to infection. These drugs counteract endothelial dysfunction, a central abnormality in these diseases. Observational studies in patients with influenza, pneumonia, sepsis and Ebola suggest they might work.
KEYWORDS:
Ebola; Pandemic influenza; angiotensin receptor blockers; host response; statins
PMID: 29058516 DOI: 10.1080/21645515.2017.1378292