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Influenza Other Respir Viruses. 2017 May 14. doi: 10.1111/irv.12458. [Epub ahead of print]
Does Influenza Pandemic Preparedness and Mitigation require Gain-Of-Function Research?
Adam DC1, Magee DJ2,3, Bui CM1, Scotch M1,2,3, MacIntyre CR1,4.
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Abstract
The risk and benefits of gain-of-function studies on influenza A has been widely debated since 2012 when the methods to create two respiratory transmissible H5N1 mutant isolates were published. Opponents of gain-of-function studies argue the biosecurity risk is unacceptable, while proponents cite potential uses for pandemic surveillance, preparedness and mitigation. In this commentary, we provide an overview of the background and applications of gain-of-function research and argue that the anticipated benefits have yet to materialize while the significant risks remain. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
influenza; pandemics; public health surveillance
PMID: 28502086 DOI: 10.1111/irv.12458
Free full text
Does Influenza Pandemic Preparedness and Mitigation require Gain-Of-Function Research?
Adam DC1, Magee DJ2,3, Bui CM1, Scotch M1,2,3, MacIntyre CR1,4.
Author information
Abstract
The risk and benefits of gain-of-function studies on influenza A has been widely debated since 2012 when the methods to create two respiratory transmissible H5N1 mutant isolates were published. Opponents of gain-of-function studies argue the biosecurity risk is unacceptable, while proponents cite potential uses for pandemic surveillance, preparedness and mitigation. In this commentary, we provide an overview of the background and applications of gain-of-function research and argue that the anticipated benefits have yet to materialize while the significant risks remain. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
influenza; pandemics; public health surveillance
PMID: 28502086 DOI: 10.1111/irv.12458
Free full text