Microbiol Immunol . Reduction of Severe Acute Respiratory Syndrome Coronavirus-2 Infectivity by Admissible Concentration of Ozone Gas and Water

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Microbiol Immunol


. 2020 Nov 24.
doi: 10.1111/1348-0421.12861. Online ahead of print.
Reduction of Severe Acute Respiratory Syndrome Coronavirus-2 Infectivity by Admissible Concentration of Ozone Gas and Water


Takayuki Murata ¹ , Satoshi Komoto ¹ , Satoko Iwahori ¹ , Jun Sasaki ¹ , Hironori Nishitsuji ¹ , Terumitsu Hasebe ² , Kiyotaka Hoshinaga ³ , Yukio Yuzawa ⁴



Affiliations

• PMID: 33230863
• DOI: 10.1111/1348-0421.12861

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the global coronavirus disease 2019 (COVID-19) pandemic. Because complete elimination of SARS-CoV-2 appears difficult, decreasing the risk of transmission is important. Treatment with 0.1 and 0.05 ppm ozone gas for 10 and 20 h, respectively, decreased SARS-CoV-2 infectivity by about 95%. The magnitude of the effect was dependent on humidity. Treatment with 1 and 2 mg/L ozone water for 10 s reduced SARS-CoV-2 infectivity by about 2 and 3 logs, respectively. Our results suggest that low-dose ozone, in the form of gas and water, is effective against SARS-CoV-2. This article is protected by copyright. All rights reserved.

Keywords: Humidity; SARS-CoV-2; TCID50; ozone gas; ozone water.