Tweet
JACC Basic Transl Sci. 2020 Apr 10. doi: 10.1016/j.jacbts.2020.04.002. [Epub ahead of print]
COVID-19 for the Cardiologist: A Current Review of the Virology, Clinical Epidemiology, Cardiac and Other Clinical Manifestations and Potential Therapeutic Strategies.
Atri D1, Siddiqi HK1, Lang J1, Nauffal V1, Morrow DA1, Bohula EA1.
Author information
Abstract
The coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), has reached pandemic status. As it spreads across the world, it has overwhelmed healthcare systems, strangled the global economy and led to a devastating loss of life. Widespread efforts from regulators, clinicians and scientists are driving a rapid expansion of knowledge of the SARS-CoV2 virus and the COVID-19 disease. We review the most current data with a focus on our basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. We discuss the basic virology, epidemiology, clinical manifestation, multi-organ consequences, and outcomes. With a focus on cardiovascular complications, we propose several mechanisms of injury. The virology and potential mechanism of injury form the basis for a discussion of potential disease-modifying therapies.
? 2020 Published by Elsevier on behalf of the American College of Cardiology Foundation.
KEYWORDS:
ACE2, angiotensin-converting enzyme 2; ARDS, acute respiratory distress syndrome; CDC, Centers for Disease Control; CFR, case fatality rate; COVID-19; COVID-19, coronavirus disease-2019; Cardiovascular; CoV, coronavirus; DIC, disseminated intravascular coagulation; ER, endoplasmic reticulum; ICU, intensive care unit; SARS-CoV1 or 2, severe acute respiratory syndrome coronavirus-1 or -2; SARS-CoV2; SOFA, sequential organ failure assessment; TMPSS2, trasmembrane serine protease-2; Treatments; Virology; hsCRP, high sensitivity c-reactive protein
PMID:32292848PMCID:PMC7151394DOI:10.1016/j.jacbts.2020.04.002
Free PMC Article