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Published:August 02, 2022
DOI: https://doi.org/10.1016/S1473-3099(22)00513-8
Daniele Lapa, Fabrizio Carletti, Valentina Mazzotta, Giulia Matusali, Carmela Pinnetti, Silvia Meschi, et al. Show all authors
... As of July 22, 2022, 16016 laboratory-con rmed monkeypox cases have been reported from 75 countries worldwide, and the WHO Director-General has declared the escalating global monkeypox outbreak to be a public health emergency of international concern.4 The vast majority of cases have been reported in Europe and other non-endemic countries, mostly diagnosed in young men, self-identifying as men who have sex with men (MSM). Monkeypox virus transmission might occur through close contact of mucosa or non-intact skin with infectious material, or large respiratory droplets during prolonged face-to-face contact.5 Whether monkeypox virus can be sexually transmitted via genital uids remains under investigation. Monkeypox virus transmission during sexual intercourse has been documented in the UK in two men with no travel history to endemic countries and evidenced by the temporal association of symptoms with sexual contact and the location of primary lesion sites matching those of sexual contact.6 Viral DNA detection in semen samples has been reported in three cases in Italy and subsequently in two patients with monkeypox in Germany.7,8 Furthermore, monkeypox DNA was detected in the seminal uid of 29 (91%) of 32 people a ected by monkeypox in a large case series on the 2022 global outbreak.9 However, to date, no evidence is available on the infectiousness of monkeypox virus in semen. Therefore, we investigated viral shedding in longitudinal semen samples collected 5–19 days after symptom onset from one con rmed monkeypox virus case diagnosed at the National Institute for Infectious Diseases ‘Lazzaro Spallanzani’ (Rome, Italy; appendix p 1). ...
https://www.thelancet.com/action/sho...2822%2900513-8
DOI: https://doi.org/10.1016/S1473-3099(22)00513-8
Daniele Lapa, Fabrizio Carletti, Valentina Mazzotta, Giulia Matusali, Carmela Pinnetti, Silvia Meschi, et al. Show all authors
... As of July 22, 2022, 16016 laboratory-con rmed monkeypox cases have been reported from 75 countries worldwide, and the WHO Director-General has declared the escalating global monkeypox outbreak to be a public health emergency of international concern.4 The vast majority of cases have been reported in Europe and other non-endemic countries, mostly diagnosed in young men, self-identifying as men who have sex with men (MSM). Monkeypox virus transmission might occur through close contact of mucosa or non-intact skin with infectious material, or large respiratory droplets during prolonged face-to-face contact.5 Whether monkeypox virus can be sexually transmitted via genital uids remains under investigation. Monkeypox virus transmission during sexual intercourse has been documented in the UK in two men with no travel history to endemic countries and evidenced by the temporal association of symptoms with sexual contact and the location of primary lesion sites matching those of sexual contact.6 Viral DNA detection in semen samples has been reported in three cases in Italy and subsequently in two patients with monkeypox in Germany.7,8 Furthermore, monkeypox DNA was detected in the seminal uid of 29 (91%) of 32 people a ected by monkeypox in a large case series on the 2022 global outbreak.9 However, to date, no evidence is available on the infectiousness of monkeypox virus in semen. Therefore, we investigated viral shedding in longitudinal semen samples collected 5–19 days after symptom onset from one con rmed monkeypox virus case diagnosed at the National Institute for Infectious Diseases ‘Lazzaro Spallanzani’ (Rome, Italy; appendix p 1). ...
https://www.thelancet.com/action/sho...2822%2900513-8
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