Extensive Lesions of Monkeypox in a Prairie Dog (Cynomys sp.) - Veterinary Pathology

[Mary Wilson]

Thread


ChristosArgyropoulos MD, PhD FlozinatorInChief
@ChristosArgyrop
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Jul 28
Intestinal Mpox lesions (arrowheads) from an infected prairie dog . Source is this paper https://journals.sagepub.com/doi/10.1354/vp.41-6-702… They also found it in many internal organs. Bottom line, the lesions don't just appear based only on how people were infected; it is a multiorgan, multisite disease

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ChristosArgyropoulos MD, PhD FlozinatorInChief
@ChristosArgyrop
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Jul 28
There has been a systematic attempt to "other" the mpox outbreak using tactics similar to those applied during the 1980s for HIV. But what do the clinical data say? https://ncbi.nlm.nih.gov/pmc/articles/PMC3322777/… https://ncbi.nlm.nih.gov/pmc/articles/PMC3320329/… https://journals.sagepub.com/doi/10.1354/vp.41-6-702…

nejm.org
The Detection of Monkeypox in Humans in the Western Hemisphere | NEJM
Original Article from The New England Journal of Medicine — The Detection of Monkeypox in Humans in the Western Hemisphere
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ChristosArgyropoulos MD, PhD FlozinatorInChief
@ChristosArgyrop
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Jul 28
The animal data are extremely interesting - unless the 2003 outbreak was due to PSP (Prairy dogs having Sex with Prairy dogs which is somewhat doubtful), the autopsy and experimental infection studies provide very interesting and relevant insights (photos from the papers)




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ChristosArgyropoulos MD, PhD FlozinatorInChief
@ChristosArgyrop
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Jul 28
But prairie dogs are not humans, so it will not be as bad in humans, right? April 2nd 1988 (I was middle school then, lol) https://pubmed.ncbi.nlm.nih.gov/2895299/ see reference 5 in that article (9 months before my birthday) https://ncbi.nlm.nih.gov/pmc/articles/PMC413801/… It likely disseminated during the viremic phase

https://twitter.com/ChristosArgyrop/status/1552770042156163073

[Mary Wilson]

American College of Veterinary Pathologists

First Published November 1, 2004

https://doi.org/10.1354/vp.41-6-702

I. M. Langohr, G. W. Stevenson, H. L. Thacker, R. L. Regnery

Abstract

Monkeypox with extensive lesions was diagnosed in a prairie dog that was involved in a recent human outbreak of monkeypox in the Midwestern United States. Gross lesions included oral ulcers, pulmonary consolidation, enlarged cervical and thoracic lymph nodes, and multifocal, small, white umbilicated plaques in the gastrointestinal wall. Microscopic lesions were extensive in the lungs and consisted of fibrinonecrotic bronchopneumonia with vasculitis and poorly defined eosinophilic intracytoplasmic inclusion bodies in cells thought to be alveolar epithelial cells, histiocytes, and fibroblasts. Multifocal necrotizing lesions, often accompanied by myxedema, were also present in most of the other examined organs. Aggregates of pox viral particles were observed within lesions by transmission electron microscopy. Monkeypox virus infection was confirmed by real-time polymerase chain reaction and virus culture at the Centers for Disease Control and Prevention. This report highlights the difficulties of rapid diagnosis of exotic or emerging diseases and further substantiates the prairie dog as an animal model of monkeypox.

https://journals.sagepub.com/doi/pdf/10.1354/vp.41-6-702