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Intern Med . A Comparison of Clinical Presentations in Coronavirus Disease 2019 Caused by Different Omicron variants in Japan: A Retrospective Study

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  • Intern Med . A Comparison of Clinical Presentations in Coronavirus Disease 2019 Caused by Different Omicron variants in Japan: A Retrospective Study

    Intern Med


    . 2023 May 24.
    doi: 10.2169/internalmedicine.1399-22. Online ahead of print. A Comparison of Clinical Presentations in Coronavirus Disease 2019 Caused by Different Omicron variants in Japan: A Retrospective Study

    Ryutaro Hirama 1 , Kenichiro Takeda 1 , Seiichiro Sakao 1 , Hajime Kasai 1 2 3 , Shizu Miyata 1 , Kohei Shikano 1 , Akira Naito 1 , Mitsuhiro Abe 1 , Takeshi Kawasaki 1 , Ayako Shigeta 1 , Taka-Aki Nakada 4 , Hidetoshi Igari 5 , Takuji Suzuki 1



    AffiliationsAbstract

    Objective We evaluated the clinical differences in coronavirus disease 2019 (COVID-19) patients between the sixth wave with the Omicron BA.1/BA.2 dominant variant (from January to April 2022) and seventh wave with the Omicron BA.5 dominant variant (from July to August 2022). Methods This retrospective, single-center, observational study included COVID-19 patients admitted to our institution in the sixth wave (sixth-wave group) and the seventh wave (seventh-wave group). Inter-group comparisons of clinical presentations, the prognosis, and proportion of nosocomial infections were performed. Results A total of 190 patients were included (93 and 97 patients in the sixth- and seventh-wave groups, respectively). While there were no significant differences in severity, significantly more patients developed pneumonia caused by COVID-19 in the sixth-wave group than in the seventh-wave group. Although there was no marked difference in in-hospital deaths, more patients died from COVID-19 in the sixth-wave group than in the seventh-wave group. There were significantly more COVID-19 inpatients with nosocomial infections in the seventh-wave group than in the sixth-wave group. Pneumonia from COVID-19 was significantly more severe in the sixth-wave group than in the seventh-wave group. Conclusions COVID-19 patients in the seventh wave are at a lower risk of pneumonia than those in the sixth wave. However, even in the seventh wave, patients with underlying diseases have a risk of death because of the exacerbation of underlying diseases triggered by COVID-19.

    Keywords: coronavirus disease 2019; nosocomial infection; omicron variant; pneumonia.

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